Adrenaline,noradrenaline inhibits insulin secretion

Q: What compounds affect the Adrenaline,noradrenaline inhibits insulin secretion pathway?

128 compounds in the BiohacksAI corpus have documented interactions with genes in the Adrenaline,noradrenaline inhibits insulin secretion pathway (Reactome ID: R-HSA-400042). These compounds target 6 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-4000426 genes128 compounds

The Adrenaline,noradrenaline inhibits insulin secretion pathway (Reactome ID: R-HSA-400042) involves 6 genes and is affected by 128 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRA2A ADRA2C CACNA1C CACNA1D CACNA2D2 GNAI1

Compounds Affecting Adrenaline,noradrenaline inhibits insulin secretion

#	Compound	Targets Hit	Studies
1	Amlodipine	—	1,000
2	Astemizole Antihistamine drug now withdrawn from	—	280
3	Yohimbine	—	299
4	Fluoxetine	—	1,000
5	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
6	Duloxetine Hydrochloride	—	993
7	Clonidine	—	299
8	Oxymetazoline	—	298
9	Norepinephrine Precursor of epinephrine that is secreted by	—	298
10	Phentolamine	—	300
11	Idazoxan	—	300
12	Epinephrine	—	299
13	Phenylephrine	—	299
14	Mianserin	—	299
15	Dexmedetomidine	—	299
16	Rilmenidine Oxazole derivative that acts as	—	300
17	Naphazoline	—	298
18	Piperoxan	—	167
19	Aripiprazole	—	298
20	Bromocriptine	—	299
21	Cabergoline	—	299
22	Dihydroergotamine	—	299
23	Guanfacine	—	294
24	Pergolide	—	299
25	Tolazoline	—	300
26	Carvedilol	—	296
27	Tamsulosin	—	298
28	Quetiapine Fumarate	—	994
29	Lisuride	—	299
30	Dihydroergotamine	—	9
31	Emetine	—	298
32	Guanabenz	—	298
33	Loxapine	—	225
34	Metergoline	—	144
35	Metoclopramide	—	297
36	Phenoxybenzamine	—	21
37	Piribedil	—	300
38	Pramipexole	—	297
39	Promethazine	—	296
40	Trazodone	—	297
41	Rutin	—	300
42	Amisulpride	—	298
43	Amoxapine	—	259
44	Buspirone	—	299
45	Chlorhexidine	—	299
46	Dihydroergocornine	—	65
47	Ergotamine	—	299
48	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
49	Indoramin	—	250
50	lidoflazine	—	278

About the Adrenaline,noradrenaline inhibits insulin secretion Pathway

The Adrenaline,noradrenaline inhibits insulin secretion pathway is catalogued in Reactome (ID: R-HSA-400042) and involves 6 genes. In the BiohacksAI corpus, 128 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRA2A, ADRA2C, CACNA1C, CACNA1D, CACNA2D2.