What compounds affect the Interleukin-12 family signaling pathway?

167 compounds in the BiohacksAI corpus have documented interactions with genes in the Interleukin-12 family signaling pathway (Reactome ID: R-HSA-447115). These compounds target 14 genes within this pathway.

What genes are in the Interleukin-12 family signaling pathway?

The Interleukin-12 family signaling pathway involves 14 genes. Key genes include: ANXA2, CA1, CDC42, CFL1, GSTO1, IFNG, JAK2, MIF, P4HB, PDCD4.

Interleukin-12 family signaling

REACTOME PATHWAY

Reactome: R-HSA-44711514 genes167 compounds

The Interleukin-12 family signaling pathway (Reactome ID: R-HSA-447115) involves 14 genes and is affected by 167 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ANXA2 CA1 CDC42 CFL1 GSTO1 IFNG JAK2 MIF P4HB PDCD4 SOD1 STAT1 STAT3 TYK2

Compounds Affecting Interleukin-12 family signaling

#	Compound	Targets Hit	Studies
1	Hexachlorophene	—	300
2	Methylene Blue	—	200
3	2-Methoxyestradiol	—	300
4	Bortezomib	—	300
5	Camptothecin	—	300
6	Dasatinib	—	299
7	Quercetin	—	300
8	Azathioprine	—	300
9	Crizotinib	—	298
10	Clotrimazole	—	296
11	Niclosamide	—	299
12	Podophyllotoxin	—	14
13	Tripterygium	—	300
14	Methotrexate	—	289
15	Astemizole Antihistamine drug now withdrawn from	—	280
16	Axitinib	—	298
17	Celecoxib	—	295
18	Cladribine	—	297
19	sp600125	—	117
20	Trifluridine	—	295
21	Histamine	—	300
22	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
23	Catechin	—	300
24	streptonigrin	—	299
25	Oxytetracycline	—	300
26	Tetracycline	—	300
27	Dacarbazine	—	299
28	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
29	Anisomycin	—	247
30	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
31	cycloheximide	—	300
32	Desoxycorticosterone Acetate	—	300
33	tyrphostin 9	—	2
34	Econazole	—	299
35	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
36	Nocodazole Nocodazole is	—	215
37	Sorafenib	—	300
38	Ursolic Acid	—	300
39	Afatinib	—	297
40	alsterpaullone	—	12
41	Chlorhexidine	—	299
42	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299
43	Clofarabine	—	298
44	Dactinomycin	—	297
45	darapladib [Supplementary Concept]	—	44
46	Daunorubicin	—	298
47	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
48	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
49	Epirubicin	—	300
50	Estrone	—	300

About the Interleukin-12 family signaling Pathway

The Interleukin-12 family signaling pathway is catalogued in Reactome (ID: R-HSA-447115) and involves 14 genes. In the BiohacksAI corpus, 167 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ANXA2, CA1, CDC42, CFL1, GSTO1.