What compounds affect the Interleukin-1 processing pathway?

91 compounds in the BiohacksAI corpus have documented interactions with genes in the Interleukin-1 processing pathway (Reactome ID: R-HSA-448706). These compounds target 7 genes within this pathway.

What genes are in the Interleukin-1 processing pathway?

The Interleukin-1 processing pathway involves 7 genes. Key genes include: CASP1, CTSG, GSDMD, IL1B, NFKB1, NFKB2, RELA.

Interleukin-1 processing

REACTOME PATHWAY

Reactome: R-HSA-4487067 genes91 compounds

The Interleukin-1 processing pathway (Reactome ID: R-HSA-448706) involves 7 genes and is affected by 91 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CASP1 CTSG GSDMD IL1B NFKB1 NFKB2 RELA

Compounds Affecting Interleukin-1 processing

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	Disulfiram	—	297
3	Bortezomib	—	300
4	Quercetin	—	300
5	Resveratrol	—	298
6	Kaempferols	—	300
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	Rutin	—	300
9	Withania	—	500
10	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
11	tamarixetin	—	26
12	withaferin	—	300
13	Hydrocortisone	—	299
14	Hydrocortisone	—	298
15	streptonigrin	—	299
16	Podophyllotoxin	—	14
17	Hexachlorophene	—	300
18	Trifluridine	—	295
19	Budesonide	—	1,000
20	Prednisolone	—	1,000
21	alsterpaullone	—	12
22	Anisomycin	—	247
23	Antipyrine	—	299
24	Astemizole Antihistamine drug now withdrawn from	—	280
25	Beclomethasone	—	300
26	Betamethasone	—	299
27	Biotin	—	297
28	Bisphenol A-Glycidyl Methacrylate	—	197
29	Carbazilquinone	—	48
30	cardamonin	—	180
31	Chlorhexidine	—	299
32	cycloheximide	—	300
33	Dichlororibofuranosylbenzimidazole	—	26
34	Diethylnitrosamine	—	300
35	Digitoxin	—	300
36	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
37	Digoxin	—	299
38	Dinitrochlorobenzene	—	300
39	Ethidium	—	300
40	Fluocinolone Acetonide	—	295
41	Fluorometholone	—	299
42	Chlorophyll Binding Proteins	—	300
43	Harmaline	—	300
44	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
45	kenpaullone	—	8
46	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
47	Levodopa	—	297
48	lidoflazine	—	278
49	Melengestrol Acetate	—	300
50	Mometasone Furoate	—	292

About the Interleukin-1 processing Pathway

The Interleukin-1 processing pathway is catalogued in Reactome (ID: R-HSA-448706) and involves 7 genes. In the BiohacksAI corpus, 91 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CASP1, CTSG, GSDMD, IL1B, NFKB1.