What compounds affect the Cardiac conduction pathway?

236 compounds in the BiohacksAI corpus have documented interactions with genes in the Cardiac conduction pathway (Reactome ID: R-HSA-5576891). These compounds target 52 genes within this pathway.

What genes are in the Cardiac conduction pathway?

The Cardiac conduction pathway involves 52 genes. Key genes include: ABCC9, ASPH, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A1.

Cardiac conduction

REACTOME PATHWAY

Reactome: R-HSA-557689152 genes236 compounds

The Cardiac conduction pathway (Reactome ID: R-HSA-5576891) involves 52 genes and is affected by 236 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC9 ASPH ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP2A1 ATP2A2 ATP2A3 CACNA1C CACNA2D2 CAMK2B CAMK2D CES1 DMPK FKBP1B FXYD2 HIPK1 HIPK2 KAT2B KCNA5 KCNE1 KCNH2 KCNJ4 KCNK10 KCNK16 KCNK18+22 more

Compounds Affecting Cardiac conduction

#	Compound	Targets Hit	Studies
1	Quinidine	—	298
2	Ouabain	—	300
3	Saxitoxin	—	300
4	Digoxin	—	299
5	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
6	Digitoxin	—	300
7	Veratridine	—	300
8	Arachidonic Acid	—	245
9	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
10	Reserpine	—	297
11	Duloxetine Hydrochloride	—	993
12	Dibucaine	—	299
13	Flunarizine Flunarizine is	—	299
14	Cyproheptadine	—	299
15	Bupivacaine	—	300
16	Clotrimazole	—	296
17	lidoflazine	—	278
18	Cinnarizine	—	299
19	dilazep	—	300
20	Hydroxyzine	—	298
21	Phentolamine	—	300
22	Promethazine	—	296
23	Carvedilol	—	296
24	Nisoldipine	—	297
25	Chlorpheniramine	—	298
26	Nortriptyline	—	295
27	protriptyline	—	296
28	Lidocaine	—	299
29	Astemizole Antihistamine drug now withdrawn from	—	280
30	Fluoxetine	—	1,000
31	Flecainide	—	297
32	Fluspirilene	—	74
33	Nitrendipine	—	299
34	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	—	287
35	Disulfiram	—	297
36	Miconazole	—	298
37	Sertraline	—	1,000
38	Crizotinib	—	298
39	Etidocaine	—	300
40	Riluzole	—	298
41	Mianserin	—	299
42	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
43	Lacosamide	—	297
44	Phenobarbital	—	297
45	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
46	Caffeine	—	299
47	Adenosine Triphosphate	—	300
48	Dantrolene Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in	—	298
49	Ryanodine	—	299
50	Sorafenib	—	300

About the Cardiac conduction Pathway

The Cardiac conduction pathway is catalogued in Reactome (ID: R-HSA-5576891) and involves 52 genes. In the BiohacksAI corpus, 236 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC9, ASPH, ATP1A1, ATP1A2, ATP1A3.