What compounds affect the Hedgehog 'on' state pathway?

214 compounds in the BiohacksAI corpus have documented interactions with genes in the Hedgehog 'on' state pathway (Reactome ID: R-HSA-5632684). These compounds target 38 genes within this pathway.

What genes are in the Hedgehog 'on' state pathway?

The Hedgehog 'on' state pathway involves 38 genes. Key genes include: ADRM1, ARRB1, CSNK1A1, GLI3, GRK2, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5.

Hedgehog 'on' state

REACTOME PATHWAY

Reactome: R-HSA-563268438 genes214 compounds

The Hedgehog 'on' state pathway (Reactome ID: R-HSA-5632684) involves 38 genes and is affected by 214 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 ARRB1 CSNK1A1 GLI3 GRK2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14+8 more

Compounds Affecting Hedgehog 'on' state

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
4	Genistein	—	300
5	Methylene Blue	—	200
6	Vitamin	—	295
7	Disulfiram	—	297
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	chrysin	—	300
10	egcg	—	300
11	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
12	Nicardipine	—	94
13	ninhydrin	—	300
14	sp600125	—	117
15	Corticosterone	—	300
16	Estrone	—	300
17	Carbaryl	—	300
18	cycloheximide	—	300
19	Hexachlorophene	—	300
20	Pueraria	—	300
21	Dehydroepiandrosterone	—	300
22	Progesterone	—	299
23	Androstenedione	—	300
24	Chlorhexidine	—	299
25	Colchicine	—	300
26	Danazol	—	298
27	Dehydroepiandrosterone	—	300
28	Dihydrotestosterone	—	300
29	Estriol	—	300
30	Ethinyl Estradiol	—	300
31	Flutamide	—	298
32	Levonorgestrel	—	292
33	Norethindrone	—	300
34	Norgestrel	—	300
35	Piperonyl Butoxide	—	300
36	Rotenone	—	300
37	Testosterone Propionate	—	300
38	propyl gallate	—	261
39	Celecoxib	—	295
40	Dinoprostone	—	296
41	Finasteride	—	296
42	Leflunomide	—	297
43	Methyltestosterone	—	300
44	Oxymetholone	—	298
45	Phenoxybenzamine	—	21
46	Podophyllotoxin	—	14
47	Budesonide	—	1,000
48	Kaempferols	—	300
49	Losartan	—	1,000
50	Resveratrol	—	298

About the Hedgehog 'on' state Pathway

The Hedgehog 'on' state pathway is catalogued in Reactome (ID: R-HSA-5632684) and involves 38 genes. In the BiohacksAI corpus, 214 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, ARRB1, CSNK1A1, GLI3, GRK2.