What compounds affect the CLEC7A/inflammasome pathway pathway?

84 compounds in the BiohacksAI corpus have documented interactions with genes in the CLEC7A/inflammasome pathway pathway (Reactome ID: R-HSA-5660668). These compounds target 3 genes within this pathway.

What genes are in the CLEC7A/inflammasome pathway pathway?

The CLEC7A/inflammasome pathway pathway involves 3 genes. Key genes include: IL1B, NFKB1, RELA.

CLEC7A/inflammasome pathway

REACTOME PATHWAY

Reactome: R-HSA-56606683 genes84 compounds

The CLEC7A/inflammasome pathway pathway (Reactome ID: R-HSA-5660668) involves 3 genes and is affected by 84 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

IL1B NFKB1 RELA

Compounds Affecting CLEC7A/inflammasome pathway

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	Hydrocortisone	—	299
3	Disulfiram	—	297
4	Hydrocortisone	—	298
5	streptonigrin	—	299
6	Quercetin	—	300
7	Resveratrol	—	298
8	Bortezomib	—	300
9	Podophyllotoxin	—	14
10	Kaempferols	—	300
11	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
12	Rutin	—	300
13	Withania	—	500
14	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
15	tamarixetin	—	26
16	Trifluridine	—	295
17	withaferin	—	300
18	Budesonide	—	1,000
19	Prednisolone	—	1,000
20	alsterpaullone	—	12
21	Anisomycin	—	247
22	Antipyrine	—	299
23	Astemizole Antihistamine drug now withdrawn from	—	280
24	Beclomethasone	—	300
25	Betamethasone	—	299
26	Biotin	—	297
27	Bisphenol A-Glycidyl Methacrylate	—	197
28	Carbazilquinone	—	48
29	cardamonin	—	180
30	Chlorhexidine	—	299
31	cycloheximide	—	300
32	Dichlororibofuranosylbenzimidazole	—	26
33	Diethylnitrosamine	—	300
34	Digitoxin	—	300
35	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
36	Digoxin	—	299
37	Dinitrochlorobenzene	—	300
38	Ethidium	—	300
39	Fluocinolone Acetonide	—	295
40	Fluorometholone	—	299
41	Chlorophyll Binding Proteins	—	300
42	Harmaline	—	300
43	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
44	kenpaullone	—	8
45	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
46	Levodopa	—	297
47	lidoflazine	—	278
48	Melengestrol Acetate	—	300
49	Mometasone Furoate	—	292
50	Nicardipine	—	94

About the CLEC7A/inflammasome pathway Pathway

The CLEC7A/inflammasome pathway pathway is catalogued in Reactome (ID: R-HSA-5660668) and involves 3 genes. In the BiohacksAI corpus, 84 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include IL1B, NFKB1, RELA.