What compounds affect the Interleukin-10 signaling pathway?

122 compounds in the BiohacksAI corpus have documented interactions with genes in the Interleukin-10 signaling pathway (Reactome ID: R-HSA-6783783). These compounds target 10 genes within this pathway.

What genes are in the Interleukin-10 signaling pathway?

The Interleukin-10 signaling pathway involves 10 genes. Key genes include: CCL2, CXCL8, FPR1, ICAM1, IL1B, IL6, PTAFR, PTGS2, STAT3, TYK2.

Interleukin-10 signaling

REACTOME PATHWAY

Reactome: R-HSA-678378310 genes122 compounds

The Interleukin-10 signaling pathway (Reactome ID: R-HSA-6783783) involves 10 genes and is affected by 122 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCL2 CXCL8 FPR1 ICAM1 IL1B IL6 PTAFR PTGS2 STAT3 TYK2

Compounds Affecting Interleukin-10 signaling

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	Prednisolone	—	1,000
3	Niclosamide	—	299
4	sp600125	—	117
5	Celecoxib	—	295
6	Indomethacin	—	297
7	Phenylbutazone	—	300
8	Tolmetin	—	298
9	Budesonide	—	1,000
10	Hydrocortisone	—	299
11	alsterpaullone	—	12
12	Anisomycin	—	247
13	Antipyrine	—	299
14	Astemizole Antihistamine drug now withdrawn from	—	280
15	Beclomethasone	—	300
16	Betamethasone	—	299
17	Biotin	—	297
18	Bisphenol A-Glycidyl Methacrylate	—	197
19	Carbazilquinone	—	48
20	cardamonin	—	180
21	Chlorhexidine	—	299
22	cycloheximide	—	300
23	Dichlororibofuranosylbenzimidazole	—	26
24	Diethylnitrosamine	—	300
25	Digitoxin	—	300
26	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
27	Digoxin	—	299
28	Dinitrochlorobenzene	—	300
29	Disulfiram	—	297
30	Ethidium	—	300
31	Fluocinolone Acetonide	—	295
32	Fluorometholone	—	299
33	Chlorophyll Binding Proteins	—	300
34	Harmaline	—	300
35	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
36	Hydrocortisone	—	298
37	kenpaullone	—	8
38	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
39	Levodopa	—	297
40	lidoflazine	—	278
41	Melengestrol Acetate	—	300
42	Mometasone Furoate	—	292
43	Nicardipine	—	94
44	Nisoldipine	—	297
45	Masoprocol	—	300
46	Nortriptyline	—	28
47	Oxyphenbutazone	—	300
48	Spironolactone	—	298
49	streptonigrin	—	299
50	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300

About the Interleukin-10 signaling Pathway

The Interleukin-10 signaling pathway is catalogued in Reactome (ID: R-HSA-6783783) and involves 10 genes. In the BiohacksAI corpus, 122 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCL2, CXCL8, FPR1, ICAM1, IL1B.