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BiohacksAI

Evidence-Based Biohacking

Patent Pending

TP53 Regulates Transcription of Cell Cycle Genes

REACTOME PATHWAY
Reactome: R-HSA-679131214 genes179 compounds

The TP53 Regulates Transcription of Cell Cycle Genes pathway (Reactome ID: R-HSA-6791312) involves 14 genes and is affected by 179 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AURKACARM1CCNA1CCNB1CCNE2CDK1CDK2EP300NPM1PCNAPLK2PLK3PRMT1TP53

Compounds Affecting TP53 Regulates Transcription of Cell Cycle Genes

#CompoundTargets HitStudies
1kenpaullone—8
2sp600125—117
3alsterpaullone—12
4Apigenin 5,7,4'-trihydroxy-flavone,—300
5chrysin—300
6Ethidium—300
7Rotenone—300
8Disulfiram—297
9Quercetin—300
10Axitinib—298
11plumbagin [Supplementary Concept]—300
12Clotrimazole—296
13Demeclocycline—5
14Clofibrate—299
15Fenofibrate—297
16Nisoldipine—297
17Sertraline—1,000
18Adenosine Triphosphate—300
19Cinnarizine—299
20Nitrofurantoin—297
21Triiodothyronine—300
22s adenosylhomocysteine—300
23indirubin—300
24fisetin—78
25Luteolin 5,7,3',4'-tetrahydroxy-flavone,—150
26Sorafenib—300
27Crizotinib—298
28Wortmannin—300
29Ethinyl Estradiol—300
30Hexachlorophene—300
31Azacitidine—298
32Azacitidine—300
33Methylene Blue—200
34Bortezomib—300
35Azathioprine—300
36Cladribine—297
37Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).—300
38Cytarabine—297
39Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as—300
40Melphalan—300
41Niclosamide—299
42Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.—300
43Methotrexate—289
44Dactinomycin—297
45Daunorubicin—298
46Glutaral—42
47Vitamin K 3—300
48Trifluridine—295
49ninhydrin—300
50o-Phthalaldehyde—300

About the TP53 Regulates Transcription of Cell Cycle Genes Pathway

The TP53 Regulates Transcription of Cell Cycle Genes pathway is catalogued in Reactome (ID: R-HSA-6791312) and involves 14 genes. In the BiohacksAI corpus, 179 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AURKA, CARM1, CCNA1, CCNB1, CCNE2.