What compounds affect the DNA Replication pathway?

101 compounds in the BiohacksAI corpus have documented interactions with genes in the DNA Replication pathway (Reactome ID: R-HSA-69306). These compounds target 45 genes within this pathway.

What genes are in the DNA Replication pathway?

The DNA Replication pathway involves 45 genes. Key genes include: ADRM1, CCNA1, CCNE2, CDC7, CDK2, CUL1, DNA2, FEN1, GMNN, KPNB1.

DNA Replication

REACTOME PATHWAY

Reactome: R-HSA-6930645 genes101 compounds

The DNA Replication pathway (Reactome ID: R-HSA-69306) involves 45 genes and is affected by 101 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CCNA1 CCNE2 CDC7 CDK2 CUL1 DNA2 FEN1 GMNN KPNB1 PCNA POLRMT PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4+15 more

Compounds Affecting DNA Replication

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	kenpaullone	—	8
4	alsterpaullone	—	12
5	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
6	Quercetin	—	300
7	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
8	sp600125	—	117
9	Disulfiram	—	297
10	Methyldopa	—	297
11	Aurintricarboxylic Acid	—	184
12	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
13	ninhydrin	—	300
14	Colchicine	—	300
15	Rotenone	—	300
16	2-Methoxyestradiol	—	300
17	Nocodazole Nocodazole is	—	215
18	Astemizole Antihistamine drug now withdrawn from	—	280
19	Metergoline	—	144
20	Podophyllotoxin	—	14
21	triflupromazine hydrochloride	—	12
22	Vorinostat	—	299
23	Calcimycin	—	216
24	Dasatinib	—	299
25	Digitoxin	—	300
26	Doxazosin	—	24
27	Ethinyl Estradiol	—	300
28	Hexachlorophene	—	300
29	Niclosamide	—	299
30	Duloxetine Hydrochloride	—	993
31	Oleic Acid	—	112
32	ag490	—	14
33	Azacitidine	—	298
34	Azacitidine	—	300
35	Calcifediol	—	300
36	Calcitriol	—	300
37	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299
38	cinacalcet	—	298
39	Clotrimazole	—	296
40	Decitabine	—	298
41	Desogestrel	—	299
42	Dibucaine	—	299
43	Digoxin	—	299
44	Ethylestrenol	—	70
45	Ethylmaleimide	—	300
46	Feprazone	—	63
47	Flunarizine Flunarizine is	—	299
48	Flunarizine Flunarizine is	—	14
49	Fluspirilene	—	74
50	gedunin	—	54

About the DNA Replication Pathway

The DNA Replication pathway is catalogued in Reactome (ID: R-HSA-69306) and involves 45 genes. In the BiohacksAI corpus, 101 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CCNA1, CCNE2, CDC7, CDK2.