What compounds affect the PTK6 Expression pathway?

184 compounds in the BiohacksAI corpus have documented interactions with genes in the PTK6 Expression pathway (Reactome ID: R-HSA-8849473). These compounds target 4 genes within this pathway.

What genes are in the PTK6 Expression pathway?

The PTK6 Expression pathway involves 4 genes. Key genes include: EPAS1, HIF1A, NR3C1, PTK6.

PTK6 Expression

REACTOME PATHWAY

Reactome: R-HSA-88494734 genes184 compounds

The PTK6 Expression pathway (Reactome ID: R-HSA-8849473) involves 4 genes and is affected by 184 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

EPAS1 HIF1A NR3C1 PTK6

Compounds Affecting PTK6 Expression

#	Compound	Targets Hit	Studies
1	cycloheximide	—	300
2	Digoxin	—	299
3	Emetine	—	298
4	Hydrocortisone	—	299
5	Hydrocortisone	—	298
6	Beclomethasone	—	300
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Desoximetasone	—	86
9	Mometasone Furoate	—	292
10	Quercetin	—	300
11	Clotrimazole	—	296
12	Nisoldipine	—	297
13	chrysin	—	300
14	Kaempferols	—	300
15	Dasatinib	—	299
16	oxatomide [Supplementary Concept] structure;	—	128
17	Phenoxybenzamine	—	21
18	triolimus [Supplementary Concept]	—	33
19	Topotecan	—	300
20	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
21	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
22	Bortezomib	—	300
23	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
24	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
25	gedunin	—	54
26	Tubercidin	—	300
27	Prednisolone	—	1,000
28	Corticosterone	—	300
29	Budesonide	—	1,000
30	Triamcinolone Acetonide	—	300
31	Megestrol Acetate Megestrol acetate is	—	300
32	Methyltestosterone	—	300
33	Prednisone	—	298
34	Triamcinolone	—	300
35	Medroxyprogesterone Acetate	—	299
36	Methylprednisolone	—	299
37	Progesterone	—	299
38	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	—	287
39	Androstenedione	—	300
40	Azacitidine	—	298
41	Azacitidine	—	300
42	Betamethasone	—	299
43	Cortisone	—	299
44	Desoxycorticosterone	—	300
45	Dihydrotestosterone	—	300
46	Fluocinolone Acetonide	—	295
47	Fluorometholone	—	299
48	Fluoxymesterone	—	278
49	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
50	Testosterone Propionate	—	300

About the PTK6 Expression Pathway

The PTK6 Expression pathway is catalogued in Reactome (ID: R-HSA-8849473) and involves 4 genes. In the BiohacksAI corpus, 184 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EPAS1, HIF1A, NR3C1, PTK6.