What compounds affect the Transcriptional regulation by RUNX1 pathway?

373 compounds in the BiohacksAI corpus have documented interactions with genes in the Transcriptional regulation by RUNX1 pathway (Reactome ID: R-HSA-8878171). These compounds target 63 genes within this pathway.

What genes are in the Transcriptional regulation by RUNX1 pathway?

The Transcriptional regulation by RUNX1 pathway involves 63 genes. Key genes include: ABL1, ADRM1, AGO2, ASH2L, BLK, CBFB, CDK6, CDK7, CREBBP, CSNK2A1.

Transcriptional regulation by RUNX1

REACTOME PATHWAY

Reactome: R-HSA-887817163 genes373 compounds

The Transcriptional regulation by RUNX1 pathway (Reactome ID: R-HSA-8878171) involves 63 genes and is affected by 373 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ADRM1 AGO2 ASH2L BLK CBFB CDK6 CDK7 CREBBP CSNK2A1 CSNK2A2 CSNK2B CTSL DPY30 EP300 ESR1 HDAC1 HIPK2 IFNG IL3 ITGA2B KAT2B KMT2A PBRM1 PRMT1 PRMT6 PSMA1 PSMA2 PSMA3 PSMA4+33 more

Compounds Affecting Transcriptional regulation by RUNX1

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Quercetin	—	300
4	chrysin	—	300
5	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
6	Sorafenib	—	300
7	s adenosylhomocysteine	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
10	Daunorubicin	—	298
11	Disulfiram	—	297
12	alsterpaullone	—	12
13	Genistein	—	300
14	Axitinib	—	298
15	Dasatinib	—	299
16	Afatinib	—	297
17	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
18	Kaempferols	—	300
19	Ethidium	—	300
20	Colchicine	—	300
21	Aurintricarboxylic Acid	—	184
22	Crizotinib	—	298
23	Nocodazole Nocodazole is	—	215
24	sp600125	—	117
25	kenpaullone	—	8
26	fisetin	—	78
27	ly294002	—	11
28	pictilisib	—	25
29	Resveratrol	—	298
30	Dactinomycin	—	297
31	cycloheximide	—	300
32	Niclosamide	—	299
33	Celecoxib	—	295
34	Podophyllotoxin	—	14
35	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
36	Camptothecin	—	300
37	tyrphostin ag 1478	—	4
38	Vanillic Acid	—	300
39	egcg	—	300
40	Harmaline	—	300
41	Levonorgestrel	—	292
42	Norgestrel	—	300
43	Ethinyl Estradiol	—	300
44	Fulvestrant	—	295
45	Estrone	—	300
46	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
47	Rotenone	—	300
48	Gestrinone	—	221
49	Hexachlorophene	—	300
50	Pueraria	—	300

About the Transcriptional regulation by RUNX1 Pathway

The Transcriptional regulation by RUNX1 pathway is catalogued in Reactome (ID: R-HSA-8878171) and involves 63 genes. In the BiohacksAI corpus, 373 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ADRM1, AGO2, ASH2L, BLK.