RUNX1 regulates transcription of genes involved in differentiation of HSCs

Q: What compounds affect the RUNX1 regulates transcription of genes involved in differentiation of HSCs pathway?

83 compounds in the BiohacksAI corpus have documented interactions with genes in the RUNX1 regulates transcription of genes involved in differentiation of HSCs pathway (Reactome ID: R-HSA-8939236). These compounds target 38 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-893923638 genes83 compounds

The RUNX1 regulates transcription of genes involved in differentiation of HSCs pathway (Reactome ID: R-HSA-8939236) involves 38 genes and is affected by 83 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ADRM1 CBFB CDK7 KMT2A PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14+8 more

Compounds Affecting RUNX1 regulates transcription of genes involved in differentiation of HSCs

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Daunorubicin	—	298
4	Genistein	—	300
5	Disulfiram	—	297
6	Aurintricarboxylic Acid	—	184
7	Harmaline	—	300
8	Nocodazole Nocodazole is	—	215
9	Sorafenib	—	300
10	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
11	Quercetin	—	300
12	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
13	Dihydroxyphenylalanine	—	300
14	Ethidium	—	300
15	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
16	Fusaric Acid	—	300
17	Colchicine	—	300
18	Resveratrol	—	298
19	Rotenone	—	300
20	Pueraria	—	300
21	Azacitidine	—	298
22	Azacitidine	—	300
23	Camptothecin	—	300
24	cycloheximide	—	300
25	Dactinomycin	—	297
26	deguelin [Supplementary Concept]	—	151
27	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
28	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
29	Ouabain	—	300
30	Podophyllotoxin	—	14
31	Thapsigargin	—	300
32	Berberine	—	300
33	2-Methoxyestradiol	—	300
34	Anisomycin	—	247
35	Antimycin	—	300
36	Azauridine	—	300
37	Benzalkonium Compounds	—	299
38	celastrol	—	300
39	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
40	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
41	dihydrorotenone	—	13
42	Emetine	—	298
43	Gliotoxin	—	300
44	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
45	Monensin	—	300
46	Monocrotaline	—	300
47	Nigericin	—	300
48	Plicamycin	—	72
49	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
50	Tilorone	—	300

About the RUNX1 regulates transcription of genes involved in differentiation of HSCs Pathway

The RUNX1 regulates transcription of genes involved in differentiation of HSCs pathway is catalogued in Reactome (ID: R-HSA-8939236) and involves 38 genes. In the BiohacksAI corpus, 83 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ADRM1, CBFB, CDK7, KMT2A.