What genes are in the RUNX2 regulates osteoblast differentiation pathway?

The RUNX2 regulates osteoblast differentiation pathway involves 11 genes. Key genes include: ABL1, AR, CBFB, GLI3, HDAC3, HDAC6, MAPK1, MAPK3, SRC, YAP1.

RUNX2 regulates osteoblast differentiation

Q: What compounds affect the RUNX2 regulates osteoblast differentiation pathway?

411 compounds in the BiohacksAI corpus have documented interactions with genes in the RUNX2 regulates osteoblast differentiation pathway (Reactome ID: R-HSA-8940973). These compounds target 11 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-894097311 genes411 compounds

The RUNX2 regulates osteoblast differentiation pathway (Reactome ID: R-HSA-8940973) involves 11 genes and is affected by 411 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 AR CBFB GLI3 HDAC3 HDAC6 MAPK1 MAPK3 SRC YAP1 YES1

Compounds Affecting RUNX2 regulates osteoblast differentiation

#	Compound	Targets Hit	Studies
1	Daunorubicin	—	298
2	Quercetin	—	300
3	Genistein	—	300
4	Sorafenib	—	300
5	Resveratrol	—	298
6	Kaempferols	—	300
7	Celecoxib	—	295
8	Dasatinib	—	299
9	Nocodazole Nocodazole is	—	215
10	tyrphostin ag 1478	—	4
11	alsterpaullone	—	12
12	kenpaullone	—	8
13	Progesterone	—	299
14	cycloheximide	—	300
15	Ethidium	—	300
16	Dactinomycin	—	297
17	Disulfiram	—	297
18	Azacitidine	—	298
19	Azacitidine	—	300
20	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
21	Clotrimazole	—	296
22	Rotenone	—	300
23	Loratadine	—	296
24	Colchicine	—	300
25	Emetine	—	298
26	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
27	Podophyllotoxin	—	14
28	chrysin	—	300
29	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
30	Imatinib Mesylate	—	300
31	Niclosamide	—	299
32	trequinsin hydrochloride	—	1
33	Febuxostat	—	297
34	triflupromazine hydrochloride	—	12
35	Pueraria	—	300
36	Camptothecin	—	300
37	pictilisib	—	25
38	Axitinib	—	298
39	pd98059	—	7
40	Crizotinib	—	298
41	Dihydrotestosterone	—	300
42	Testosterone	—	299
43	Medroxyprogesterone Acetate	—	299
44	Spironolactone	—	298
45	Flutamide	—	298
46	Levonorgestrel	—	292
47	Norgestrel	—	300
48	Androstenedione	—	300
49	Ethinyl Estradiol	—	300
50	Testosterone Propionate	—	300

About the RUNX2 regulates osteoblast differentiation Pathway

The RUNX2 regulates osteoblast differentiation pathway is catalogued in Reactome (ID: R-HSA-8940973) and involves 11 genes. In the BiohacksAI corpus, 411 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, AR, CBFB, GLI3, HDAC3.