What compounds affect the Signaling by NOTCH4 pathway?

108 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by NOTCH4 pathway (Reactome ID: R-HSA-9013694). These compounds target 48 genes within this pathway.

What genes are in the Signaling by NOTCH4 pathway?

The Signaling by NOTCH4 pathway involves 48 genes. Key genes include: ADAM10, ADRM1, APH1A, APH1B, CREBBP, CUL1, EP300, FLT4, KAT2A, KAT2B.

Signaling by NOTCH4

REACTOME PATHWAY

Reactome: R-HSA-901369448 genes108 compounds

The Signaling by NOTCH4 pathway (Reactome ID: R-HSA-9013694) involves 48 genes and is affected by 108 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM10 ADRM1 APH1A APH1B CREBBP CUL1 EP300 FLT4 KAT2A KAT2B NCSTN PSEN1 PSEN2 PSENEN PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2+18 more

Compounds Affecting Signaling by NOTCH4

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Dihydroergocristine	—	187
4	egcg	—	300
5	Hexachlorophene	—	300
6	alsterpaullone	—	12
7	Disulfiram	—	297
8	kenpaullone	—	8
9	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
10	Kaempferols	—	300
11	Quercetin	—	300
12	Colchicine	—	300
13	chrysin	—	300
14	Nocodazole Nocodazole is	—	215
15	streptonigrin	—	299
16	candesartan cilexetil [Supplementary Concept]	—	300
17	Oxytetracycline	—	300
18	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
19	plumbagin [Supplementary Concept]	—	300
20	ninhydrin	—	300
21	Calcimycin	—	216
22	cycloheximide	—	300
23	Anisomycin	—	247
24	Azacitidine	—	298
25	Azacitidine	—	300
26	Nisoldipine	—	297
27	Tubercidin	—	300
28	cardamonin	—	180
29	Dactinomycin	—	297
30	Danazol	—	298
31	Dasatinib	—	299
32	Dinitrochlorobenzene	—	300
33	Ethidium	—	300
34	Flutamide	—	298
35	Loratadine	—	296
36	Oxyphenbutazone	—	300
37	Podophyllotoxin	—	14
38	vinblastine sulfate	—	81
39	Vincristine	—	299
40	Fluoxetine	—	1,000
41	Methylene Blue	—	200
42	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
43	Astemizole Antihistamine drug now withdrawn from	—	280
44	Celecoxib	—	295
45	Ciclopirox	—	88
46	Cladribine	—	297
47	Daunorubicin	—	298
48	Digitoxin	—	300
49	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
50	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135

About the Signaling by NOTCH4 Pathway

The Signaling by NOTCH4 pathway is catalogued in Reactome (ID: R-HSA-9013694) and involves 48 genes. In the BiohacksAI corpus, 108 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM10, ADRM1, APH1A, APH1B, CREBBP.