What compounds affect the Biosynthesis of maresins pathway?

554 compounds in the BiohacksAI corpus have documented interactions with genes in the Biosynthesis of maresins pathway (Reactome ID: R-HSA-9018682). These compounds target 8 genes within this pathway.

What genes are in the Biosynthesis of maresins pathway?

The Biosynthesis of maresins pathway involves 8 genes. Key genes include: ALOX5, CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4, EPHX2.

Biosynthesis of maresins

REACTOME PATHWAY

Reactome: R-HSA-90186828 genes554 compounds

The Biosynthesis of maresins pathway (Reactome ID: R-HSA-9018682) involves 8 genes and is affected by 554 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALOX5 CYP1A2 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP3A4 EPHX2

Compounds Affecting Biosynthesis of maresins

#	Compound	Targets Hit	Studies
1	Kaempferols	—	300
2	Clotrimazole	—	296
3	Quercetin	—	300
4	Chlorhexidine	—	299
5	Methoxsalen	—	300
6	Amoxapine	—	259
7	Celecoxib	—	295
8	Danazol	—	298
9	Piribedil	—	300
10	Tolazamide	—	169
11	Ethoxyquin Antioxidant; also	—	180
12	Piperonyl Butoxide	—	300
13	Methylene Blue	—	200
14	Ethidium	—	300
15	Melphalan	—	300
16	Vitamin K 3	—	300
17	Miconazole	—	298
18	oxatomide [Supplementary Concept] structure;	—	128
19	Phenelzine	—	2
20	Reserpine	—	297
21	Sulindac	—	297
22	Melatonin	—	297
23	Flutamide	—	298
24	Fluvoxamine	—	297
25	Nisoldipine	—	297
26	Phenelzine	—	297
27	Phenylthiourea Phenylthiourea is	—	300
28	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
29	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
30	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
31	amlexanox	—	96
32	Bufexamac	—	137
33	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
34	Lumefantrine	—	299
35	Nialamide	—	300
36	Niclosamide	—	299
37	Pueraria	—	300
38	Simvastatin	—	1,000
39	Axitinib	—	298
40	Carbaryl	—	300
41	Disulfiram	—	297
42	Edaravone	—	298
43	Ethanolamine	—	300
44	Farnesol	—	300
45	Iodoacetamide	—	300
46	Isoniazid Antibacterial agent used primarily as	—	299
47	Leflunomide	—	297
48	pd98059	—	7
49	Propanil	—	293
50	Rotenone	—	300

About the Biosynthesis of maresins Pathway

The Biosynthesis of maresins pathway is catalogued in Reactome (ID: R-HSA-9018682) and involves 8 genes. In the BiohacksAI corpus, 554 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALOX5, CYP1A2, CYP2C8, CYP2C9, CYP2D6.