What compounds affect the Interleukin-2 signaling pathway?

205 compounds in the BiohacksAI corpus have documented interactions with genes in the Interleukin-2 signaling pathway (Reactome ID: R-HSA-9020558). These compounds target 5 genes within this pathway.

What genes are in the Interleukin-2 signaling pathway?

The Interleukin-2 signaling pathway involves 5 genes. Key genes include: JAK3, LCK, PTK2B, STAT5A, SYK.

Interleukin-2 signaling

REACTOME PATHWAY

Reactome: R-HSA-90205585 genes205 compounds

The Interleukin-2 signaling pathway (Reactome ID: R-HSA-9020558) involves 5 genes and is affected by 205 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

JAK3 LCK PTK2B STAT5A SYK

Compounds Affecting Interleukin-2 signaling

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	Sorafenib	—	300
3	sp600125	—	117
4	Axitinib	—	298
5	Dasatinib	—	299
6	Methotrexate	—	289
7	cycloheximide	—	300
8	piceatannol	—	300
9	tyrphostin ag 1478	—	4
10	Afatinib	—	297
11	kenpaullone	—	8
12	Ouabain	—	300
13	Atorvastatin	—	1,000
14	Simvastatin	—	1,000
15	Chlorhexidine	—	299
16	Clofarabine	—	298
17	Colchicine	—	300
18	deguelin [Supplementary Concept]	—	151
19	Digoxin	—	299
20	Disulfiram	—	297
21	Emetine	—	298
22	Ezetimibe	—	296
23	Lovastatin	—	300
24	Medroxyprogesterone Acetate	—	299
25	Melphalan	—	300
26	Mometasone Furoate	—	292
27	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
28	Niclosamide	—	299
29	Podophyllotoxin	—	14
30	Thapsigargin	—	300
31	torin 1	—	10
32	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
33	Trifluridine	—	295
34	fisetin	—	78
35	ag490	—	14
36	alpelisib	—	227
37	Azathioprine	—	300
38	Bortezomib	—	300
39	Maprotiline	—	299
40	Nocodazole Nocodazole is	—	215
41	N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept]	—	8
42	Tripterygium	—	300
43	Vincristine	—	299
44	withaferin	—	300
45	Berberine	—	300
46	cbd	—	298
47	Doxycycline	—	999
48	Methylene Blue	—	200
49	Minocycline	—	297
50	Sertraline	—	1,000

About the Interleukin-2 signaling Pathway

The Interleukin-2 signaling pathway is catalogued in Reactome (ID: R-HSA-9020558) and involves 5 genes. In the BiohacksAI corpus, 205 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include JAK3, LCK, PTK2B, STAT5A, SYK.