What compounds affect the Interleukin-12 signaling pathway?

163 compounds in the BiohacksAI corpus have documented interactions with genes in the Interleukin-12 signaling pathway (Reactome ID: R-HSA-9020591). These compounds target 12 genes within this pathway.

What genes are in the Interleukin-12 signaling pathway?

The Interleukin-12 signaling pathway involves 12 genes. Key genes include: ANXA2, CA1, CDC42, CFL1, GSTO1, IFNG, JAK2, MIF, P4HB, PDCD4.

Interleukin-12 signaling

REACTOME PATHWAY

Reactome: R-HSA-902059112 genes163 compounds

The Interleukin-12 signaling pathway (Reactome ID: R-HSA-9020591) involves 12 genes and is affected by 163 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ANXA2 CA1 CDC42 CFL1 GSTO1 IFNG JAK2 MIF P4HB PDCD4 SOD1 TYK2

Compounds Affecting Interleukin-12 signaling

#	Compound	Targets Hit	Studies
1	2-Methoxyestradiol	—	300
2	Hexachlorophene	—	300
3	Bortezomib	—	300
4	Camptothecin	—	300
5	Dasatinib	—	299
6	Quercetin	—	300
7	Azathioprine	—	300
8	Crizotinib	—	298
9	Clotrimazole	—	296
10	Podophyllotoxin	—	14
11	Tripterygium	—	300
12	Methotrexate	—	289
13	Astemizole Antihistamine drug now withdrawn from	—	280
14	Axitinib	—	298
15	Cladribine	—	297
16	sp600125	—	117
17	Trifluridine	—	295
18	Histamine	—	300
19	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
20	Catechin	—	300
21	Methylene Blue	—	200
22	Oxytetracycline	—	300
23	Tetracycline	—	300
24	Dacarbazine	—	299
25	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
26	Anisomycin	—	247
27	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
28	cycloheximide	—	300
29	Desoxycorticosterone Acetate	—	300
30	tyrphostin 9	—	2
31	Econazole	—	299
32	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
33	Nocodazole Nocodazole is	—	215
34	Sorafenib	—	300
35	Ursolic Acid	—	300
36	Afatinib	—	297
37	alsterpaullone	—	12
38	Chlorhexidine	—	299
39	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299
40	Clofarabine	—	298
41	Dactinomycin	—	297
42	darapladib [Supplementary Concept]	—	44
43	Daunorubicin	—	298
44	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
45	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
46	Epirubicin	—	300
47	Estrone	—	300
48	Ethinyl Estradiol	—	300
49	Fulvestrant	—	295
50	Idarubicin	—	299

About the Interleukin-12 signaling Pathway

The Interleukin-12 signaling pathway is catalogued in Reactome (ID: R-HSA-9020591) and involves 12 genes. In the BiohacksAI corpus, 163 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ANXA2, CA1, CDC42, CFL1, GSTO1.