What genes are in the MECP2 regulates neuronal receptors and channels pathway?

The MECP2 regulates neuronal receptors and channels pathway involves 12 genes. Key genes include: CREB1, FKBP5, GRIA2, GRIN2A, GRIN2B, HDAC1, HDAC2, MET, OPRK1, OPRM1.

MECP2 regulates neuronal receptors and channels

Q: What compounds affect the MECP2 regulates neuronal receptors and channels pathway?

142 compounds in the BiohacksAI corpus have documented interactions with genes in the MECP2 regulates neuronal receptors and channels pathway (Reactome ID: R-HSA-9022699). These compounds target 12 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-902269912 genes142 compounds

The MECP2 regulates neuronal receptors and channels pathway (Reactome ID: R-HSA-9022699) involves 12 genes and is affected by 142 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREB1 FKBP5 GRIA2 GRIN2A GRIN2B HDAC1 HDAC2 MET OPRK1 OPRM1 PTPN1 SLC2A3

Compounds Affecting MECP2 regulates neuronal receptors and channels

#	Compound	Targets Hit	Studies
1	Levorphanol	—	297
2	Ibogaine	—	300
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	Celecoxib	—	295
5	Bortezomib	—	300
6	Ethidium	—	300
7	Daunorubicin	—	298
8	Glutamic Acid	—	297
9	Glutamic Acid	—	300
10	Ursolic Acid	—	300
11	Morphine	—	294
12	Naloxone	—	299
13	Fentanyl	—	300
14	Nalbuphine	—	298
15	Butorphanol	—	299
16	Oxycodone	—	298
17	Nalorphine	—	300
18	Pentazocine	—	299
19	Diprenorphine	—	295
20	Sufentanil	—	298
21	Levallorphan	—	289
22	Meperidine	—	297
23	Codeine	—	295
24	Etorphine	—	300
25	cbd	—	298
26	cannabidiol	—	296
27	Dihydromorphine	—	300
28	Alfentanil	—	298
29	Hydromorphone	—	297
30	Cyclazocine	—	300
31	hydrocodone	—	294
32	Kaempferols	—	300
33	beta-Endorphin	—	300
34	Buprenorphine	—	297
35	Flunarizine Flunarizine is	—	14
36	Phenazocine	—	80
37	alphitonin [Supplementary Concept] from	—	300
38	Quercetin	—	300
39	Glycine	—	300
40	pentamidine	—	299
41	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
42	Aspartic Acid	—	300
43	cycloserine	—	298
44	D-Aspartic Acid	—	29
45	Dextrorphan Dextro form of levorphanol. It acts as	—	300
46	Memantine AMANTADINE derivative that has some dopaminergic effects. It has been proposed as	—	34
47	Dextrothyroxine	—	134
48	Dizocilpine Maleate	—	300
49	Ibotenic Acid	—	300
50	Spermine	—	300

About the MECP2 regulates neuronal receptors and channels Pathway

The MECP2 regulates neuronal receptors and channels pathway is catalogued in Reactome (ID: R-HSA-9022699) and involves 12 genes. In the BiohacksAI corpus, 142 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREB1, FKBP5, GRIA2, GRIN2A, GRIN2B.