What compounds affect the NR1H2 and NR1H3-mediated signaling pathway?

103 compounds in the BiohacksAI corpus have documented interactions with genes in the NR1H2 and NR1H3-mediated signaling pathway (Reactome ID: R-HSA-9024446). These compounds target 16 genes within this pathway.

What genes are in the NR1H2 and NR1H3-mediated signaling pathway?

The NR1H2 and NR1H3-mediated signaling pathway involves 16 genes. Key genes include: AGO2, EP300, FASN, HDAC3, KDM1A, KDM4A, NCOA1, NCOR1, NCOR2, NR1H2.

NR1H2 and NR1H3-mediated signaling

REACTOME PATHWAY

Reactome: R-HSA-902444616 genes103 compounds

The NR1H2 and NR1H3-mediated signaling pathway (Reactome ID: R-HSA-9024446) involves 16 genes and is affected by 103 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AGO2 EP300 FASN HDAC3 KDM1A KDM4A NCOA1 NCOR1 NCOR2 NR1H2 NR1H3 PLIN1 RXRA RXRB SREBF1 UGT1A3

Compounds Affecting NR1H2 and NR1H3-mediated signaling

#	Compound	Targets Hit	Studies
1	Vorinostat	—	299
2	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
3	methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate [Supplementary Concept]	—	161
4	Thyroxine	—	994
5	Progesterone	—	299
6	Calcitriol	—	300
7	Thyroxine	—	300
8	Quercetin	—	300
9	Gemfibrozil	—	297
10	scriptaid	—	53
11	egcg	—	300
12	Desmosterol	—	300
13	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
14	Dehydroepiandrosterone Sulfate	—	300
15	Sulindac	—	297
16	Vitamin	—	295
17	Aldosterone	—	300
18	Dactinomycin	—	297
19	Domperidone	—	299
20	Ethylene Chlorohydrin Used as	—	73
21	Phenol	—	297
22	Retinaldehyde	—	300
23	Ribitol	—	297
24	Sorbic Acid Mold and yeast inhibitor. Used as	—	300
25	Stavudine	—	298
26	Sulfanilamide	—	300
27	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
28	Xylitol	—	300
29	Arachidonic Acid	—	245
30	Genistein	—	300
31	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
32	Testosterone	—	299
33	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
34	Acetylcysteine	—	298
35	Adenosine	—	298
36	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
37	Chloral Hydrate	—	298
38	Chloralose	—	300
39	Cilostazol	—	297
40	Diflubenzuron	—	300
41	Dihydrotestosterone	—	300
42	dimethyl formamide	—	260
43	Dimethylformamide	—	300
44	Diuron	—	300
45	Ethidium	—	300
46	Ezetimibe	—	296
47	Flutamide	—	298
48	Lutein	—	300
49	Niclosamide	—	299
50	Niflumic Acid	—	300

About the NR1H2 and NR1H3-mediated signaling Pathway

The NR1H2 and NR1H3-mediated signaling pathway is catalogued in Reactome (ID: R-HSA-9024446) and involves 16 genes. In the BiohacksAI corpus, 103 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AGO2, EP300, FASN, HDAC3, KDM1A.