NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux

Q: What compounds affect the NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux pathway?

93 compounds in the BiohacksAI corpus have documented interactions with genes in the NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux pathway (Reactome ID: R-HSA-9029569). These compounds target 12 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-902956912 genes93 compounds

The NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux pathway (Reactome ID: R-HSA-9029569) involves 12 genes and is affected by 93 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AGO2 EP300 HDAC3 KDM1A KDM4A NCOA1 NCOR1 NCOR2 NR1H2 NR1H3 RXRA RXRB

Compounds Affecting NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux

#	Compound	Targets Hit	Studies
1	Vorinostat	—	299
2	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
3	methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate [Supplementary Concept]	—	161
4	Thyroxine	—	994
5	Progesterone	—	299
6	Calcitriol	—	300
7	Thyroxine	—	300
8	Quercetin	—	300
9	Gemfibrozil	—	297
10	scriptaid	—	53
11	Desmosterol	—	300
12	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
13	Dehydroepiandrosterone Sulfate	—	300
14	Sulindac	—	297
15	Vitamin	—	295
16	Aldosterone	—	300
17	Dactinomycin	—	297
18	Domperidone	—	299
19	Ethylene Chlorohydrin Used as	—	73
20	Phenol	—	297
21	Retinaldehyde	—	300
22	Ribitol	—	297
23	Sorbic Acid Mold and yeast inhibitor. Used as	—	300
24	Stavudine	—	298
25	Sulfanilamide	—	300
26	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
27	Xylitol	—	300
28	Arachidonic Acid	—	245
29	Genistein	—	300
30	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
31	Testosterone	—	299
32	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
33	Acetylcysteine	—	298
34	Adenosine	—	298
35	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
36	Chloral Hydrate	—	298
37	Chloralose	—	300
38	Cilostazol	—	297
39	Diflubenzuron	—	300
40	Dihydrotestosterone	—	300
41	dimethyl formamide	—	260
42	Dimethylformamide	—	300
43	Diuron	—	300
44	Ethidium	—	300
45	Ezetimibe	—	296
46	Flutamide	—	298
47	Lutein	—	300
48	Niclosamide	—	299
49	Niflumic Acid	—	300
50	Nitrofurazone	—	300

About the NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Pathway

The NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux pathway is catalogued in Reactome (ID: R-HSA-9029569) and involves 12 genes. In the BiohacksAI corpus, 93 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AGO2, EP300, HDAC3, KDM1A, KDM4A.