What compounds affect the Chaperone Mediated Autophagy pathway?

122 compounds in the BiohacksAI corpus have documented interactions with genes in the Chaperone Mediated Autophagy pathway (Reactome ID: R-HSA-9613829). These compounds target 6 genes within this pathway.

What genes are in the Chaperone Mediated Autophagy pathway?

The Chaperone Mediated Autophagy pathway involves 6 genes. Key genes include: CFTR, HBB, HDAC6, HSP90AA1, HSP90AB1, HSPA8.

Chaperone Mediated Autophagy

REACTOME PATHWAY

Reactome: R-HSA-96138296 genes122 compounds

The Chaperone Mediated Autophagy pathway (Reactome ID: R-HSA-9613829) involves 6 genes and is affected by 122 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CFTR HBB HDAC6 HSP90AA1 HSP90AB1 HSPA8

Compounds Affecting Chaperone Mediated Autophagy

#	Compound	Targets Hit	Studies
1	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
2	Hexachlorophene	—	300
3	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
4	Quercetin	—	300
5	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
6	piceatannol	—	300
7	Genistein	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	cycloheximide	—	300
10	Vorinostat	—	299
11	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
12	Vitamin K 3	—	300
13	Disulfiram	—	297
14	scriptaid	—	53
15	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
16	Camptothecin	—	300
17	triolimus [Supplementary Concept]	—	33
18	monorden	—	8
19	gedunin	—	54
20	celastrol	—	300
21	Novobiocin	—	300
22	caffeic acid	—	300
23	Masoprocol	—	300
24	Tetracycline	—	300
25	ag490	—	14
26	Idarubicin	—	299
27	Nitroprusside	—	299
28	Anisomycin	—	247
29	kenpaullone	—	8
30	Hydrocortisone	—	299
31	Betamethasone	—	299
32	Bumetanide	—	299
33	Chlorthalidone	—	299
34	Ethidium	—	300
35	Hydrocortisone	—	298
36	Cervugid [Supplementary Concept]	—	300
37	Medroxyprogesterone Acetate	—	299
38	Mestranol	—	300
39	Nisoldipine	—	297
40	Quinestrol	—	194
41	Budesonide	—	1,000
42	Methylene Blue	—	200
43	Prednisolone	—	1,000
44	6-Aminonicotinamide	—	300
45	alsterpaullone	—	12
46	Hyoscyamine	—	296
47	Beclomethasone	—	300
48	Carbazilquinone	—	48
49	Carbidopa	—	298
50	cardamonin	—	180

About the Chaperone Mediated Autophagy Pathway

The Chaperone Mediated Autophagy pathway is catalogued in Reactome (ID: R-HSA-9613829) and involves 6 genes. In the BiohacksAI corpus, 122 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CFTR, HBB, HDAC6, HSP90AA1, HSP90AB1.