What compounds affect the Diseases of programmed cell death pathway?

243 compounds in the BiohacksAI corpus have documented interactions with genes in the Diseases of programmed cell death pathway (Reactome ID: R-HSA-9645723). These compounds target 17 genes within this pathway.

What genes are in the Diseases of programmed cell death pathway?

The Diseases of programmed cell death pathway involves 17 genes. Key genes include: APP, BCL2L11, CAPN1, CDC25A, CDC25B, CDK5, CDK5R1, DNMT1, DNMT3B, EED.

Diseases of programmed cell death

REACTOME PATHWAY

Reactome: R-HSA-964572317 genes243 compounds

The Diseases of programmed cell death pathway (Reactome ID: R-HSA-9645723) involves 17 genes and is affected by 243 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APP BCL2L11 CAPN1 CDC25A CDC25B CDK5 CDK5R1 DNMT1 DNMT3B EED EZH2 FOXO3 JUN LMNA PRDX1 RIPK3 TP53

Compounds Affecting Diseases of programmed cell death

#	Compound	Targets Hit	Studies
1	egcg	—	300
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	Vitamin K 3	—	300
4	Methylene Blue	—	200
5	Disulfiram	—	297
6	Quercetin	—	300
7	plumbagin [Supplementary Concept]	—	300
8	Resveratrol	—	298
9	chrysin	—	300
10	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
11	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
12	s adenosylhomocysteine	—	300
13	Azacitidine	—	298
14	Azacitidine	—	300
15	Bortezomib	—	300
16	Rotenone	—	300
17	Cladribine	—	297
18	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
19	Trifluridine	—	295
20	ninhydrin	—	300
21	Clotrimazole	—	296
22	Methylnitronitrosoguanidine	—	52
23	Thioridazine	—	35
24	vinblastine sulfate	—	81
25	Clofibrate	—	299
26	Decitabine	—	298
27	Digitoxin	—	300
28	Digoxin	—	299
29	Fenofibrate	—	297
30	Nisoldipine	—	297
31	Nocodazole Nocodazole is	—	215
32	Oxyphenbutazone	—	300
33	sp600125	—	117
34	triflupromazine hydrochloride	—	12
35	Vincristine	—	299
36	Sertraline	—	1,000
37	Amoxapine	—	259
38	Astemizole Antihistamine drug now withdrawn from	—	280
39	Chlormadinone Acetate	—	300
40	Cinnarizine	—	299
41	Colchicine	—	300
42	ethopropazine hydrochloride	—	2
43	Ethynodiol Diacetate	—	300
44	Maprotiline	—	299
45	Robenidine	—	162
46	Salmeterol Xinafoate	—	227
47	Podophyllotoxin	—	14
48	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
49	kenpaullone	—	8
50	alsterpaullone	—	12

About the Diseases of programmed cell death Pathway

The Diseases of programmed cell death pathway is catalogued in Reactome (ID: R-HSA-9645723) and involves 17 genes. In the BiohacksAI corpus, 243 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, BCL2L11, CAPN1, CDC25A, CDC25B.