What genes are in the Purinergic signaling in leishmaniasis infection pathway?

The Purinergic signaling in leishmaniasis infection pathway involves 13 genes. Key genes include: APP, CASP1, CTSG, ENTPD5, GSDMD, HSP90AB1, IL1B, NFKB1, NFKB2, NLRP3.

Purinergic signaling in leishmaniasis infection

Q: What compounds affect the Purinergic signaling in leishmaniasis infection pathway?

132 compounds in the BiohacksAI corpus have documented interactions with genes in the Purinergic signaling in leishmaniasis infection pathway (Reactome ID: R-HSA-9660826). These compounds target 13 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-966082613 genes132 compounds

The Purinergic signaling in leishmaniasis infection pathway (Reactome ID: R-HSA-9660826) involves 13 genes and is affected by 132 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APP CASP1 CTSG ENTPD5 GSDMD HSP90AB1 IL1B NFKB1 NFKB2 NLRP3 P2RX4 P2RX7 RELA

Compounds Affecting Purinergic signaling in leishmaniasis infection

#	Compound	Targets Hit	Studies
1	Disulfiram	—	297
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	Quercetin	—	300
4	Bortezomib	—	300
5	Resveratrol	—	298
6	Kaempferols	—	300
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	streptonigrin	—	299
9	Podophyllotoxin	—	14
10	Rutin	—	300
11	Withania	—	500
12	Hexachlorophene	—	300
13	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
14	tamarixetin	—	26
15	Trifluridine	—	295
16	withaferin	—	300
17	Hydrocortisone	—	299
18	Anisomycin	—	247
19	Chlorhexidine	—	299
20	cycloheximide	—	300
21	Digitoxin	—	300
22	Digoxin	—	299
23	Hydrocortisone	—	298
24	Niclosamide	—	299
25	Masoprocol	—	300
26	tyrphostin 9	—	2
27	egcg	—	300
28	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
29	caffeic acid	—	300
30	Ethinyl Estradiol	—	300
31	Thioridazine	—	35
32	Adenosine Triphosphate	—	300
33	Budesonide	—	1,000
34	Prednisolone	—	1,000
35	alsterpaullone	—	12
36	Antipyrine	—	299
37	Astemizole Antihistamine drug now withdrawn from	—	280
38	Beclomethasone	—	300
39	Betamethasone	—	299
40	Biotin	—	297
41	Bisphenol A-Glycidyl Methacrylate	—	197
42	Carbazilquinone	—	48
43	cardamonin	—	180
44	Dichlororibofuranosylbenzimidazole	—	26
45	Diethylnitrosamine	—	300
46	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
47	Dinitrochlorobenzene	—	300
48	Ethidium	—	300
49	Fluocinolone Acetonide	—	295
50	Fluorometholone	—	299

About the Purinergic signaling in leishmaniasis infection Pathway

The Purinergic signaling in leishmaniasis infection pathway is catalogued in Reactome (ID: R-HSA-9660826) and involves 13 genes. In the BiohacksAI corpus, 132 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, CASP1, CTSG, ENTPD5, GSDMD.