What compounds affect the Leishmania phagocytosis pathway?

227 compounds in the BiohacksAI corpus have documented interactions with genes in the Leishmania phagocytosis pathway (Reactome ID: R-HSA-9664417). These compounds target 13 genes within this pathway.

What genes are in the Leishmania phagocytosis pathway?

The Leishmania phagocytosis pathway involves 13 genes. Key genes include: ABL1, BTK, CDC42, FGR, FYN, GRB2, HCK, LYN, MAPK1, MAPK3.

Leishmania phagocytosis

REACTOME PATHWAY

Reactome: R-HSA-966441713 genes227 compounds

The Leishmania phagocytosis pathway (Reactome ID: R-HSA-9664417) involves 13 genes and is affected by 227 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 BTK CDC42 FGR FYN GRB2 HCK LYN MAPK1 MAPK3 SRC SYK YES1

Compounds Affecting Leishmania phagocytosis

#	Compound	Targets Hit	Studies
1	tyrphostin ag 1478	—	4
2	Sorafenib	—	300
3	Dasatinib	—	299
4	Crizotinib	—	298
5	kenpaullone	—	8
6	alsterpaullone	—	12
7	Axitinib	—	298
8	Afatinib	—	297
9	Quercetin	—	300
10	sp600125	—	117
11	withaferin	—	300
12	pd98059	—	7
13	Niclosamide	—	299
14	fisetin	—	78
15	alpelisib	—	227
16	Nocodazole Nocodazole is	—	215
17	casin	—	10
18	Cladribine	—	297
19	Clotrimazole	—	296
20	monorden	—	8
21	pictilisib	—	25
22	triolimus [Supplementary Concept]	—	33
23	trequinsin hydrochloride	—	1
24	Vemurafenib	—	298
25	Kaempferols	—	300
26	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
27	daph	—	2
28	Loratadine	—	296
29	plumbagin [Supplementary Concept]	—	300
30	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
31	trametinib	—	296
32	Genistein	—	300
33	Ouabain	—	300
34	Atorvastatin	—	1,000
35	Simvastatin	—	1,000
36	Methotrexate	—	289
37	Chlorhexidine	—	299
38	Clofarabine	—	298
39	Colchicine	—	300
40	cycloheximide	—	300
41	deguelin [Supplementary Concept]	—	151
42	Digoxin	—	299
43	Disulfiram	—	297
44	Emetine	—	298
45	Ezetimibe	—	296
46	Lovastatin	—	300
47	Medroxyprogesterone Acetate	—	299
48	Melphalan	—	300
49	Mometasone Furoate	—	292
50	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300

About the Leishmania phagocytosis Pathway

The Leishmania phagocytosis pathway is catalogued in Reactome (ID: R-HSA-9664417) and involves 13 genes. In the BiohacksAI corpus, 227 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, BTK, CDC42, FGR, FYN.