What genes are in the Defective Intrinsic Pathway for Apoptosis pathway?

The Defective Intrinsic Pathway for Apoptosis pathway involves 12 genes. Key genes include: APP, BCL2L11, CAPN1, CDC25A, CDC25B, CDK5, CDK5R1, FOXO3, JUN, LMNA.

Defective Intrinsic Pathway for Apoptosis

Q: What compounds affect the Defective Intrinsic Pathway for Apoptosis pathway?

232 compounds in the BiohacksAI corpus have documented interactions with genes in the Defective Intrinsic Pathway for Apoptosis pathway (Reactome ID: R-HSA-9734009). These compounds target 12 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-973400912 genes232 compounds

The Defective Intrinsic Pathway for Apoptosis pathway (Reactome ID: R-HSA-9734009) involves 12 genes and is affected by 232 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APP BCL2L11 CAPN1 CDC25A CDC25B CDK5 CDK5R1 FOXO3 JUN LMNA PRDX1 TP53

Compounds Affecting Defective Intrinsic Pathway for Apoptosis

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	Vitamin K 3	—	300
3	egcg	—	300
4	Methylene Blue	—	200
5	Disulfiram	—	297
6	plumbagin [Supplementary Concept]	—	300
7	Resveratrol	—	298
8	chrysin	—	300
9	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
10	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
11	Bortezomib	—	300
12	Rotenone	—	300
13	Cladribine	—	297
14	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
15	Trifluridine	—	295
16	Quercetin	—	300
17	ninhydrin	—	300
18	Clotrimazole	—	296
19	Methylnitronitrosoguanidine	—	52
20	Thioridazine	—	35
21	vinblastine sulfate	—	81
22	Clofibrate	—	299
23	Digitoxin	—	300
24	Digoxin	—	299
25	Fenofibrate	—	297
26	Nisoldipine	—	297
27	Nocodazole Nocodazole is	—	215
28	Oxyphenbutazone	—	300
29	sp600125	—	117
30	triflupromazine hydrochloride	—	12
31	Vincristine	—	299
32	Sertraline	—	1,000
33	Amoxapine	—	259
34	Chlormadinone Acetate	—	300
35	Cinnarizine	—	299
36	Colchicine	—	300
37	ethopropazine hydrochloride	—	2
38	Ethynodiol Diacetate	—	300
39	Maprotiline	—	299
40	Robenidine	—	162
41	Salmeterol Xinafoate	—	227
42	Podophyllotoxin	—	14
43	kenpaullone	—	8
44	alsterpaullone	—	12
45	indirubin	—	300
46	fisetin	—	78
47	Ethidium	—	300
48	Ethinyl Estradiol	—	300
49	Hexachlorophene	—	300
50	Azacitidine	—	298

About the Defective Intrinsic Pathway for Apoptosis Pathway

The Defective Intrinsic Pathway for Apoptosis pathway is catalogued in Reactome (ID: R-HSA-9734009) and involves 12 genes. In the BiohacksAI corpus, 232 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, BCL2L11, CAPN1, CDC25A, CDC25B.