What compounds affect the Aspirin ADME pathway?

575 compounds in the BiohacksAI corpus have documented interactions with genes in the Aspirin ADME pathway (Reactome ID: R-HSA-9749641). These compounds target 20 genes within this pathway.

What genes are in the Aspirin ADME pathway?

The Aspirin ADME pathway involves 20 genes. Key genes include: ABCC2, ABCC3, ALB, BCHE, CES1, CES2, CYP2C19, CYP2C8, CYP2C9, CYP2D6.

Aspirin ADME

REACTOME PATHWAY

Reactome: R-HSA-974964120 genes575 compounds

The Aspirin ADME pathway (Reactome ID: R-HSA-9749641) involves 20 genes and is affected by 575 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC2 ABCC3 ALB BCHE CES1 CES2 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP3A4 SLC22A7 SLCO2B1 UGT1A1 UGT1A3 UGT1A4 UGT1A6 UGT1A9 UGT2B7

Compounds Affecting Aspirin ADME

#	Compound	Targets Hit	Studies
1	Glyburide	—	298
2	Delavirdine	—	296
3	Ritonavir	—	298
4	Clotrimazole	—	296
5	Quercetin	—	300
6	Ethinyl Estradiol	—	300
7	Flutamide	—	298
8	Phenylbutazone	—	300
9	Sulindac	—	297
10	Pueraria	—	300
11	Danazol	—	298
12	Troglitazone	—	299
13	cbd	—	298
14	cannabidiol	—	296
15	Edaravone	—	298
16	Nitrendipine	—	299
17	Reserpine	—	297
18	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
19	Simvastatin	—	1,000
20	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
21	Cefoperazone Semisynthetic broad-spectrum cephalosporin with	—	300
22	Ceftriaxone	—	299
23	Quinidine	—	298
24	Disulfiram	—	297
25	Isoniazid Antibacterial agent used primarily as	—	299
26	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
27	Methoxsalen	—	300
28	Rotenone	—	300
29	Carbaryl	—	300
30	Chlorhexidine	—	299
31	Ethoxyquin Antioxidant; also	—	180
32	Loratadine	—	296
33	Vitamin K 3	—	300
34	Piribedil	—	300
35	Tolazamide	—	169
36	Genistein	—	300
37	Lovastatin	—	300
38	Mestranol	—	300
39	Nisoldipine	—	297
40	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
41	Kaempferols	—	300
42	Melatonin	—	297
43	Methylene Blue	—	200
44	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	—	287
45	Anastrozole	—	298
46	Celecoxib	—	295
47	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
48	Ethidium	—	300
49	Gemfibrozil	—	297
50	Hexachlorophene	—	300

About the Aspirin ADME Pathway

The Aspirin ADME pathway is catalogued in Reactome (ID: R-HSA-9749641) and involves 20 genes. In the BiohacksAI corpus, 575 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC2, ABCC3, ALB, BCHE, CES1.