What compounds affect the Atorvastatin ADME pathway?

347 compounds in the BiohacksAI corpus have documented interactions with genes in the Atorvastatin ADME pathway (Reactome ID: R-HSA-9754706). These compounds target 8 genes within this pathway.

What genes are in the Atorvastatin ADME pathway?

The Atorvastatin ADME pathway involves 8 genes. Key genes include: ABCB1, ABCC2, CYP3A4, PON1, SLCO1B1, SLCO1B3, SLCO2B1, UGT1A3.

Atorvastatin ADME

REACTOME PATHWAY

Reactome: R-HSA-97547068 genes347 compounds

The Atorvastatin ADME pathway (Reactome ID: R-HSA-9754706) involves 8 genes and is affected by 347 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCB1 ABCC2 CYP3A4 PON1 SLCO1B1 SLCO1B3 SLCO2B1 UGT1A3

Compounds Affecting Atorvastatin ADME

#	Compound	Targets Hit	Studies
1	Ritonavir	—	298
2	Glyburide	—	298
3	Quercetin	—	300
4	Genistein	—	300
5	Atorvastatin	—	1,000
6	Simvastatin	—	1,000
7	Losartan	—	1,000
8	candesartan cilexetil [Supplementary Concept]	—	300
9	Delavirdine	—	296
10	Mometasone Furoate	—	292
11	Vincristine	—	299
12	Thyroxine	—	994
13	Thyroxine	—	300
14	Triiodothyronine	—	300
15	Antimycin	—	300
16	Gemfibrozil	—	297
17	Olmesartan Medoxomil	—	300
18	Rifamycins	—	300
19	Rifamycins	—	300
20	Silymarin	—	10
21	Clotrimazole	—	296
22	Disulfiram	—	297
23	Methoxsalen	—	300
24	Miconazole	—	298
25	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
26	Lovastatin	—	300
27	Ethinyl Estradiol	—	300
28	Isoniazid Antibacterial agent used primarily as	—	299
29	Rotenone	—	300
30	Levonorgestrel	—	292
31	Norgestrel	—	300
32	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
33	Budesonide	—	1,000
34	Testosterone	—	299
35	Melphalan	—	300
36	Niclosamide	—	299
37	Nisoldipine	—	297
38	Phenelzine	—	2
39	Podophyllotoxin	—	14
40	chrysin	—	300
41	egcg	—	300
42	Amoxapine	—	259
43	Danazol	—	298
44	Flutamide	—	298
45	Lynestrenol	—	299
46	Vitamin K 3	—	300
47	Methylprednisolone	—	299
48	Norethindrone	—	300
49	Troglitazone	—	299
50	vinblastine sulfate	—	81

About the Atorvastatin ADME Pathway

The Atorvastatin ADME pathway is catalogued in Reactome (ID: R-HSA-9754706) and involves 8 genes. In the BiohacksAI corpus, 347 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCB1, ABCC2, CYP3A4, PON1, SLCO1B1.