What compounds affect the Prednisone ADME pathway?

342 compounds in the BiohacksAI corpus have documented interactions with genes in the Prednisone ADME pathway (Reactome ID: R-HSA-9757110). These compounds target 8 genes within this pathway.

What genes are in the Prednisone ADME pathway?

The Prednisone ADME pathway involves 8 genes. Key genes include: ABCB1, AKR1C1, ALB, CYP3A4, HSD11B1, SERPINA6, UGT1A3, UGT2B7.

Prednisone ADME

REACTOME PATHWAY

Reactome: R-HSA-97571108 genes342 compounds

The Prednisone ADME pathway (Reactome ID: R-HSA-9757110) involves 8 genes and is affected by 342 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCB1 AKR1C1 ALB CYP3A4 HSD11B1 SERPINA6 UGT1A3 UGT2B7

Compounds Affecting Prednisone ADME

#	Compound	Targets Hit	Studies
1	Testosterone	—	299
2	egcg	—	300
3	Dihydrotestosterone	—	300
4	Ritonavir	—	298
5	Clotrimazole	—	296
6	Disulfiram	—	297
7	Methoxsalen	—	300
8	Miconazole	—	298
9	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
10	Glyburide	—	298
11	Lovastatin	—	300
12	Quercetin	—	300
13	Ethinyl Estradiol	—	300
14	Isoniazid Antibacterial agent used primarily as	—	299
15	Rotenone	—	300
16	Levonorgestrel	—	292
17	Norgestrel	—	300
18	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
19	Budesonide	—	1,000
20	Melphalan	—	300
21	Niclosamide	—	299
22	Nisoldipine	—	297
23	Phenelzine	—	2
24	Podophyllotoxin	—	14
25	chrysin	—	300
26	Simvastatin	—	1,000
27	Amoxapine	—	259
28	Danazol	—	298
29	Flutamide	—	298
30	Lynestrenol	—	299
31	Vitamin K 3	—	300
32	Methylprednisolone	—	299
33	Norethindrone	—	300
34	vinblastine sulfate	—	81
35	Kaempferols	—	300
36	Hexachlorophene	—	300
37	Nicardipine	—	94
38	Reserpine	—	297
39	Sulfinpyrazone	—	300
40	cbd	—	298
41	vinpocetine	—	299
42	Astemizole Antihistamine drug now withdrawn from	—	280
43	cannabidiol	—	296
44	Chlorhexidine	—	299
45	Daunorubicin	—	298
46	Delavirdine	—	296
47	Equilin	—	216
48	Phenylbutazone	—	300
49	Quinidine	—	298
50	tyrphostin 9	—	2

About the Prednisone ADME Pathway

The Prednisone ADME pathway is catalogued in Reactome (ID: R-HSA-9757110) and involves 8 genes. In the BiohacksAI corpus, 342 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCB1, AKR1C1, ALB, CYP3A4, HSD11B1.