What genes are in the GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 pathway?

The GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 pathway involves 36 genes. Key genes include: ADRM1, CUL1, GSK3B, NFE2L2, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6.

GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2

Q: What compounds affect the GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 pathway?

218 compounds in the BiohacksAI corpus have documented interactions with genes in the GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 pathway (Reactome ID: R-HSA-9762114). These compounds target 36 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-976211436 genes218 compounds

The GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 pathway (Reactome ID: R-HSA-9762114) involves 36 genes and is affected by 218 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CUL1 GSK3B NFE2L2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2+6 more

Compounds Affecting GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	Quercetin	—	300
5	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
6	chrysin	—	300
7	ninhydrin	—	300
8	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
9	Genistein	—	300
10	Kaempferols	—	300
11	Oleanolic Acid	—	300
12	sp600125	—	117
13	Disulfiram	—	297
14	candesartan cilexetil [Supplementary Concept]	—	300
15	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
16	ly294002	—	11
17	egcg	—	300
18	Resveratrol	—	298
19	Colchicine	—	300
20	Vitamin	—	295
21	Azacitidine	—	298
22	Azacitidine	—	300
23	alpha-Linolenic Acid	—	300
24	Oxymetholone	—	298
25	Rotenone	—	300
26	Methylene Blue	—	200
27	Ethoxyquin Antioxidant; also	—	180
28	Nitrofurazone	—	300
29	Azathioprine	—	300
30	Mestranol	—	300
31	methoprene	—	300
32	Niclosamide	—	299
33	Phenelzine	—	2
34	vinblastine sulfate	—	81
35	alyssin [Supplementary Concept]	—	300
36	Digitoxin	—	300
37	Digoxin	—	299
38	Flutamide	—	298
39	Hexachlorophene	—	300
40	Linoleic Acid	—	300
41	Vitamin K 3	—	300
42	Nitrofurantoin	—	297
43	Ouabain	—	300
44	Podophyllotoxin	—	14
45	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
46	Toxaphene	—	299
47	DEAD-box RNA Helicases	—	169
48	Thioctic Acid	—	298
49	amlexanox	—	96
50	Chlormadinone Acetate	—	300

About the GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Pathway

The GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 pathway is catalogued in Reactome (ID: R-HSA-9762114) and involves 36 genes. In the BiohacksAI corpus, 218 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CUL1, GSK3B, NFE2L2, PSMA1.