Developmental Cell Lineages of the Exocrine Pancreas

Q: What compounds affect the Developmental Cell Lineages of the Exocrine Pancreas pathway?

173 compounds in the BiohacksAI corpus have documented interactions with genes in the Developmental Cell Lineages of the Exocrine Pancreas pathway (Reactome ID: R-HSA-9820448). These compounds target 9 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-98204489 genes173 compounds

The Developmental Cell Lineages of the Exocrine Pancreas pathway (Reactome ID: R-HSA-9820448) involves 9 genes and is affected by 173 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ANXA2 CA2 CD74 CFTR GNMT PLA2G1B PNLIP PRSS1 YAP1

Compounds Affecting Developmental Cell Lineages of the Exocrine Pancreas

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Genistein	—	300
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	Anisomycin	—	247
5	cycloheximide	—	300
6	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	Bumetanide	—	299
9	Chlorthalidone	—	299
10	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
11	Disulfiram	—	297
12	Hexachlorophene	—	300
13	Nocodazole Nocodazole is	—	215
14	Podophyllotoxin	—	14
15	rafoxanide	—	172
16	scriptaid	—	53
17	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
18	Thiorphan	—	300
19	Tilorone	—	300
20	Tubercidin	—	300
21	Bortezomib	—	300
22	Resveratrol	—	298
23	2-Methoxyestradiol	—	300
24	tyrphostin 9	—	2
25	Crizotinib	—	298
26	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
27	kenpaullone	—	8
28	Vorinostat	—	299
29	Hydrocortisone	—	299
30	Betamethasone	—	299
31	Ethidium	—	300
32	Hydrocortisone	—	298
33	Cervugid [Supplementary Concept]	—	300
34	Medroxyprogesterone Acetate	—	299
35	Vitamin K 3	—	300
36	Mestranol	—	300
37	Nisoldipine	—	297
38	Quinestrol	—	194
39	Budesonide	—	1,000
40	Methylene Blue	—	200
41	Prednisolone	—	1,000
42	6-Aminonicotinamide	—	300
43	alsterpaullone	—	12
44	Hyoscyamine	—	296
45	Beclomethasone	—	300
46	Carbazilquinone	—	48
47	Carbidopa	—	298
48	cardamonin	—	180
49	Desoximetasone	—	86
50	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300

About the Developmental Cell Lineages of the Exocrine Pancreas Pathway

The Developmental Cell Lineages of the Exocrine Pancreas pathway is catalogued in Reactome (ID: R-HSA-9820448) and involves 9 genes. In the BiohacksAI corpus, 173 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ANXA2, CA2, CD74, CFTR, GNMT.