Regulation of MITF-M-dependent genes involved in pigmentation

Q: What compounds affect the Regulation of MITF-M-dependent genes involved in pigmentation pathway?

96 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of MITF-M-dependent genes involved in pigmentation pathway (Reactome ID: R-HSA-9824585). These compounds target 5 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-98245855 genes96 compounds

The Regulation of MITF-M-dependent genes involved in pigmentation pathway (Reactome ID: R-HSA-9824585) involves 5 genes and is affected by 96 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREB1 MAPK14 MITF SMARCA2 TYR

Compounds Affecting Regulation of MITF-M-dependent genes involved in pigmentation

#	Compound	Targets Hit	Studies
1	chrysin	—	300
2	Ethidium	—	300
3	egcg	—	300
4	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
5	cycloheximide	—	300
6	Oxyphenbutazone	—	300
7	Anisomycin	—	247
8	Azacitidine	—	298
9	Azacitidine	—	300
10	Bortezomib	—	300
11	Ciclopirox	—	88
12	Nocodazole Nocodazole is	—	215
13	Disulfiram	—	297
14	Genistein	—	300
15	Quercetin	—	300
16	Dasatinib	—	299
17	Cefdinir	—	298
18	Oxytetracycline	—	300
19	colchine	—	2
20	Anthralin	—	299
21	Aurintricarboxylic Acid	—	184
22	Biotin	—	297
23	Rolitetracycline	—	166
24	Rutin	—	300
25	Topotecan	—	300
26	Methylene Blue	—	200
27	Rosmarinic Acid	—	300
28	Astemizole Antihistamine drug now withdrawn from	—	280
29	Calcimycin	—	216
30	Camptothecin	—	300
31	Carmine Coloring matter from	—	300
32	celastrol	—	300
33	clofilium tosylate	—	4
34	Demecolcine	—	246
35	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
36	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
37	Digoxin	—	299
38	Droxidopa	—	202
39	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
40	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
41	Levodopa	—	297
42	Niclosamide	—	299
43	pictilisib	—	25
44	Podophyllotoxin	—	14
45	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
46	torin 1	—	10
47	tyrphostin 9	—	2
48	vinblastine sulfate	—	81
49	Vincristine	—	299
50	Vorinostat	—	299

About the Regulation of MITF-M-dependent genes involved in pigmentation Pathway

The Regulation of MITF-M-dependent genes involved in pigmentation pathway is catalogued in Reactome (ID: R-HSA-9824585) and involves 5 genes. In the BiohacksAI corpus, 96 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREB1, MAPK14, MITF, SMARCA2, TYR.