Regulation of MITF-M-dependent genes involved in cell cycle and proliferation

Q: What compounds affect the Regulation of MITF-M-dependent genes involved in cell cycle and proliferation pathway?

83 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of MITF-M-dependent genes involved in cell cycle and proliferation pathway (Reactome ID: R-HSA-9825892). These compounds target 8 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-98258928 genes83 compounds

The Regulation of MITF-M-dependent genes involved in cell cycle and proliferation pathway (Reactome ID: R-HSA-9825892) involves 8 genes and is affected by 83 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCNB1 CDC25B CDK2 HDAC1 MET MITF PLK1 TCF7L2

Compounds Affecting Regulation of MITF-M-dependent genes involved in cell cycle and proliferation

#	Compound	Targets Hit	Studies
1	Aurintricarboxylic Acid	—	184
2	Oxytetracycline	—	300
3	egcg	—	300
4	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
5	Oxyphenbutazone	—	300
6	Bortezomib	—	300
7	Camptothecin	—	300
8	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
9	pictilisib	—	25
10	Vorinostat	—	299
11	Quercetin	—	300
12	Methylergonovine	—	14
13	sp600125	—	117
14	kenpaullone	—	8
15	alsterpaullone	—	12
16	Cefdinir	—	298
17	Ethidium	—	300
18	colchine	—	2
19	Anthralin	—	299
20	Biotin	—	297
21	Rolitetracycline	—	166
22	Rutin	—	300
23	cycloheximide	—	300
24	Topotecan	—	300
25	Methylene Blue	—	200
26	Rosmarinic Acid	—	300
27	Anisomycin	—	247
28	Astemizole Antihistamine drug now withdrawn from	—	280
29	Azacitidine	—	298
30	Azacitidine	—	300
31	Calcimycin	—	216
32	Carmine Coloring matter from	—	300
33	celastrol	—	300
34	Ciclopirox	—	88
35	clofilium tosylate	—	4
36	Demecolcine	—	246
37	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
38	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
39	Digoxin	—	299
40	Droxidopa	—	202
41	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
42	Levodopa	—	297
43	Niclosamide	—	299
44	Nocodazole Nocodazole is	—	215
45	Podophyllotoxin	—	14
46	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
47	torin 1	—	10
48	tyrphostin 9	—	2
49	vinblastine sulfate	—	81
50	Vincristine	—	299

About the Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Pathway

The Regulation of MITF-M-dependent genes involved in cell cycle and proliferation pathway is catalogued in Reactome (ID: R-HSA-9825892) and involves 8 genes. In the BiohacksAI corpus, 83 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNB1, CDC25B, CDK2, HDAC1, MET.