Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Q: What compounds affect the Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway?

208 compounds in the BiohacksAI corpus have documented interactions with genes in the Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway (Reactome ID: R-HSA-983695). These compounds target 9 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-9836959 genes208 compounds

The Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway (Reactome ID: R-HSA-983695) involves 9 genes and is affected by 208 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BLK BTK FYN GRB2 LYN PIK3CD PIK3R1 PTPN6 SYK

Compounds Affecting Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	Crizotinib	—	298
3	tyrphostin ag 1478	—	4
4	Sorafenib	—	300
5	sp600125	—	117
6	torin 1	—	10
7	alpelisib	—	227
8	ly294002	—	11
9	pictilisib	—	25
10	alsterpaullone	—	12
11	kenpaullone	—	8
12	Axitinib	—	298
13	Afatinib	—	297
14	celastrol	—	300
15	Quercetin	—	300
16	Ku 0063794 [Supplementary Concept]	—	7
17	Wortmannin	—	300
18	Sirolimus	—	300
19	Ouabain	—	300
20	Atorvastatin	—	1,000
21	Simvastatin	—	1,000
22	Methotrexate	—	289
23	Chlorhexidine	—	299
24	Clofarabine	—	298
25	Colchicine	—	300
26	cycloheximide	—	300
27	deguelin [Supplementary Concept]	—	151
28	Digoxin	—	299
29	Disulfiram	—	297
30	Emetine	—	298
31	Ezetimibe	—	296
32	Lovastatin	—	300
33	Medroxyprogesterone Acetate	—	299
34	Melphalan	—	300
35	Mometasone Furoate	—	292
36	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
37	Niclosamide	—	299
38	piceatannol	—	300
39	Podophyllotoxin	—	14
40	Thapsigargin	—	300
41	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
42	Trifluridine	—	295
43	fisetin	—	78
44	ag490	—	14
45	Azathioprine	—	300
46	Bortezomib	—	300
47	Maprotiline	—	299
48	Nocodazole Nocodazole is	—	215
49	N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept]	—	8
50	Tripterygium	—	300

About the Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Pathway

The Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway is catalogued in Reactome (ID: R-HSA-983695) and involves 9 genes. In the BiohacksAI corpus, 208 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BLK, BTK, FYN, GRB2, LYN.