MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis

Q: What compounds affect the MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis pathway?

178 compounds in the BiohacksAI corpus have documented interactions with genes in the MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis pathway (Reactome ID: R-HSA-9841922). These compounds target 22 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-984192222 genes178 compounds

The MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis pathway (Reactome ID: R-HSA-9841922) involves 22 genes and is affected by 178 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ASH2L CCNC CDK5 CDK8 CREBBP DPY30 EP300 FABP4 HDAC3 MGLL NCOA1 NCOA3 NCOR1 NCOR2 NR5A2 PLIN1 PPARG RBBP5 RXRA SIRT1 WDR5

Compounds Affecting MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis

#	Compound	Targets Hit	Studies
1	Methylene Blue	—	200
2	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
3	Methotrexate	—	289
4	cycloheximide	—	300
5	Sorafenib	—	300
6	alsterpaullone	—	12
7	s adenosylhomocysteine	—	300
8	Genistein	—	300
9	urolithin b	—	49
10	Ethidium	—	300
11	Arachidonic Acid	—	245
12	Quercetin	—	300
13	Biotin	—	297
14	Nocodazole Nocodazole is	—	215
15	Anisomycin	—	247
16	Azacitidine	—	298
17	Azacitidine	—	300
18	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
19	Digoxin	—	299
20	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
21	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
22	Tubercidin	—	300
23	Vorinostat	—	299
24	Thyroxine	—	994
25	Thyroxine	—	300
26	Rotenone	—	300
27	Linoleic Acid	—	300
28	Triiodothyronine	—	300
29	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
30	chrysin	—	300
31	Resveratrol	—	298
32	Disulfiram	—	297
33	Niflumic Acid	—	300
34	Oxaprozin	—	181
35	Dehydroepiandrosterone Sulfate	—	300
36	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
37	Oleic Acid	—	112
38	Vitamin	—	295
39	Dactinomycin	—	297
40	Dasatinib	—	299
41	Daunorubicin	—	298
42	methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate [Supplementary Concept]	—	161
43	Ezetimibe	—	296
44	Famotidine	—	296
45	Retinaldehyde	—	300
46	vinblastine sulfate	—	81
47	Progesterone	—	299
48	Aldosterone	—	300
49	Cilostazol	—	297
50	Gemfibrozil	—	297

About the MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Pathway

The MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis pathway is catalogued in Reactome (ID: R-HSA-9841922) and involves 22 genes. In the BiohacksAI corpus, 178 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ASH2L, CCNC, CDK5, CDK8.