What compounds affect the Dengue Virus-Host Interactions pathway?

86 compounds in the BiohacksAI corpus have documented interactions with genes in the Dengue Virus-Host Interactions pathway (Reactome ID: R-HSA-9918481). These compounds target 21 genes within this pathway.

What genes are in the Dengue Virus-Host Interactions pathway?

The Dengue Virus-Host Interactions pathway involves 21 genes. Key genes include: CAMK2B, CAMK2D, CGAS, ELAVL1, FASN, HNRNPA1, HSP90AA1, HSP90AB1, HSPA8, IKBKE.

Dengue Virus-Host Interactions

REACTOME PATHWAY

Reactome: R-HSA-991848121 genes86 compounds

The Dengue Virus-Host Interactions pathway (Reactome ID: R-HSA-9918481) involves 21 genes and is affected by 86 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CAMK2B CAMK2D CGAS ELAVL1 FASN HNRNPA1 HSP90AA1 HSP90AB1 HSPA8 IKBKE MAPKAP1 MLST8 MTOR NEK2 NFKBIA PIK3C3 PTBP1 RICTOR RPTOR SF3B3 TAOK1

Compounds Affecting Dengue Virus-Host Interactions

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	torin 1	—	10
3	Ku 0063794 [Supplementary Concept]	—	7
4	Hexachlorophene	—	300
5	Idarubicin	—	299
6	sp600125	—	117
7	triolimus [Supplementary Concept]	—	33
8	gedunin	—	54
9	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
10	Disulfiram	—	297
11	Wortmannin	—	300
12	Sirolimus	—	300
13	Everolimus	—	297
14	egcg	—	300
15	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
16	monorden	—	8
17	celastrol	—	300
18	Novobiocin	—	300
19	caffeic acid	—	300
20	Masoprocol	—	300
21	Tetracycline	—	300
22	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
23	ag490	—	14
24	Calcimycin	—	216
25	piceatannol	—	300
26	Nitroprusside	—	299
27	pictilisib	—	25
28	Camptothecin	—	300
29	Dequalinium	—	136
30	amlexanox	—	96
31	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
32	Sorafenib	—	300
33	Crizotinib	—	298
34	2-Chloroadenosine 2-Chloroadenosine.	—	300
35	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
36	Calcitriol	—	300
37	Ciclopirox	—	88
38	Clotrimazole	—	296
39	cycloheximide	—	300
40	deguelin [Supplementary Concept]	—	151
41	Indazoles	—	300
42	Miconazole	—	298
43	specioside	—	6
44	ly294002	—	11
45	Rotenone	—	300
46	Thapsigargin	—	300
47	alpelisib	—	227
48	amn082	—	29
49	Idazoxan	—	300
50	Niclosamide	—	299

About the Dengue Virus-Host Interactions Pathway

The Dengue Virus-Host Interactions pathway is catalogued in Reactome (ID: R-HSA-9918481) and involves 21 genes. In the BiohacksAI corpus, 86 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CAMK2B, CAMK2D, CGAS, ELAVL1, FASN.