What genes are in the Developmental Lineage of Pancreatic Ductal Cells pathway?

The Developmental Lineage of Pancreatic Ductal Cells pathway involves 5 genes. Key genes include: ANXA2, CA2, CD74, CFTR, YAP1.

Developmental Lineage of Pancreatic Ductal Cells

Q: What compounds affect the Developmental Lineage of Pancreatic Ductal Cells pathway?

139 compounds in the BiohacksAI corpus have documented interactions with genes in the Developmental Lineage of Pancreatic Ductal Cells pathway (Reactome ID: R-HSA-9925563). These compounds target 5 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-99255635 genes139 compounds

The Developmental Lineage of Pancreatic Ductal Cells pathway (Reactome ID: R-HSA-9925563) involves 5 genes and is affected by 139 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ANXA2 CA2 CD74 CFTR YAP1

Compounds Affecting Developmental Lineage of Pancreatic Ductal Cells

#	Compound	Targets Hit	Studies
1	Genistein	—	300
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	Anisomycin	—	247
4	cycloheximide	—	300
5	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
6	Bumetanide	—	299
7	Chlorthalidone	—	299
8	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
9	Nocodazole Nocodazole is	—	215
10	Podophyllotoxin	—	14
11	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
12	Tilorone	—	300
13	Tubercidin	—	300
14	Resveratrol	—	298
15	kenpaullone	—	8
16	Vorinostat	—	299
17	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
18	Hydrocortisone	—	299
19	Betamethasone	—	299
20	Ethidium	—	300
21	Hydrocortisone	—	298
22	Cervugid [Supplementary Concept]	—	300
23	Medroxyprogesterone Acetate	—	299
24	Vitamin K 3	—	300
25	Mestranol	—	300
26	Nisoldipine	—	297
27	Quinestrol	—	194
28	Budesonide	—	1,000
29	Methylene Blue	—	200
30	Prednisolone	—	1,000
31	6-Aminonicotinamide	—	300
32	alsterpaullone	—	12
33	Hyoscyamine	—	296
34	Beclomethasone	—	300
35	Carbazilquinone	—	48
36	Carbidopa	—	298
37	cardamonin	—	180
38	Desoximetasone	—	86
39	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
40	Digoxin	—	299
41	Dinitrochlorobenzene	—	300
42	Disulfiram	—	297
43	Flumethasone	—	179
44	Fluocinolone Acetonide	—	295
45	Fluorometholone	—	299
46	Flurandrenolone	—	65
47	gamma-Linolenic Acid	—	300
48	Glyburide	—	298
49	Halcinonide	—	88
50	Hexachlorophene	—	300

About the Developmental Lineage of Pancreatic Ductal Cells Pathway

The Developmental Lineage of Pancreatic Ductal Cells pathway is catalogued in Reactome (ID: R-HSA-9925563) and involves 5 genes. In the BiohacksAI corpus, 139 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ANXA2, CA2, CD74, CFTR, YAP1.