What genes are in the RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression pathway?

The RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression pathway involves 11 genes. Key genes include: CARM1, CREBBP, EP300, HDAC3, NCOA1, NCOR1, NR1D1, PPARA, RORA, RXRA.

RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression

Q: What compounds affect the RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression pathway?

107 compounds in the BiohacksAI corpus have documented interactions with genes in the RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression pathway (Reactome ID: R-HSA-9933387). These compounds target 11 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-993338711 genes107 compounds

The RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression pathway (Reactome ID: R-HSA-9933387) involves 11 genes and is affected by 107 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CARM1 CREBBP EP300 HDAC3 NCOA1 NCOR1 NR1D1 PPARA RORA RXRA SREBF1

Compounds Affecting RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression

#	Compound	Targets Hit	Studies
1	Aldosterone	—	300
2	Gemfibrozil	—	297
3	Progesterone	—	299
4	Arachidonic Acid	—	245
5	Ursolic Acid	—	300
6	Vorinostat	—	299
7	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
8	Dehydroepiandrosterone Sulfate	—	300
9	methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate [Supplementary Concept]	—	161
10	Sulindac	—	297
11	Thyroxine	—	994
12	Vitamin	—	295
13	Calcitriol	—	300
14	Dactinomycin	—	297
15	Domperidone	—	299
16	Ethylene Chlorohydrin Used as	—	73
17	Phenol	—	297
18	Retinaldehyde	—	300
19	Ribitol	—	297
20	Sorbic Acid Mold and yeast inhibitor. Used as	—	300
21	Stavudine	—	298
22	Sulfanilamide	—	300
23	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
24	Thyroxine	—	300
25	Xylitol	—	300
26	Genistein	—	300
27	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
28	Quercetin	—	300
29	Testosterone	—	299
30	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
31	Acetylcysteine	—	298
32	Adenosine	—	298
33	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
34	Chloral Hydrate	—	298
35	Chloralose	—	300
36	Cilostazol	—	297
37	Diflubenzuron	—	300
38	Dihydrotestosterone	—	300
39	dimethyl formamide	—	260
40	Dimethylformamide	—	300
41	Diuron	—	300
42	Ethidium	—	300
43	Ezetimibe	—	296
44	Flutamide	—	298
45	Lutein	—	300
46	Niclosamide	—	299
47	Niflumic Acid	—	300
48	Nitrofurazone	—	300
49	Oxaprozin	—	181
50	Piperazine	—	299

About the RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression Pathway

The RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression pathway is catalogued in Reactome (ID: R-HSA-9933387) and involves 11 genes. In the BiohacksAI corpus, 107 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CARM1, CREBBP, EP300, HDAC3, NCOA1.