How BiohacksAI works
BiohacksAI is an AI-driven compound research and discovery platform built on 1.12 million PubMed studies, a deterministic graph of 9,238 substances, and a cryptographic evidence chain called X-Vault.
The platform does two things: it lets researchers query the scientific literature with evidence-grade answers, and it systematically discovers novel compound–pathway combinations that may have drug-discovery value.
The evidence layer
Every claim in BiohacksAI is backed by a specific PubMed study. The corpus is a curated, versioned snapshot of PubMed abstracts indexed by substance, target, pathway, and study type.
The corpus is locked at a specific version — currently v20260307-01. When you query the system you always get an answer from the same dataset, and every answer includes a Merkle root hash that proves which version was used.
How discoveries are generated
The discovery engine scans the corpus for compounds that have strong biological target coverage but low literature footprint — meaning the scientific community has not yet fully characterised them.
These candidates are ranked by a two-layer scoring system and sealed cryptographically into the X-Vault evidence chain.
Discovery score and biotech score
Every compound is evaluated by two complementary scores. The discovery score measures biological breadth. The biotech score measures drug-discovery relevance.
Compounds with many validated targets, broad pathway coverage, and low literature footprint score highest. The log-damping on studies ensures that well-studied compounds are de-prioritised in favour of understudied ones.
Target relevance is a weighted sum based on the HIGH_VALUE_TARGETS registry — 60+ gene symbols classified as Tier 3 (kinases, transcription factors, metabolic regulators: EGFR, NFE2L2, MTOR, SIRT1, TP53, BRD4, JAK1…) or Tier 2 (research-grade: MAPK1, SOD1, APP, HDAC2…). A compound that hits a Tier 3 target scores higher than one that hits an unstudied gene.
Cryptographic evidence sealing
Every discovery is sealed into the X-Vault — an append-only, SHA-256 hash-chained log that provides a cryptographically verifiable record of when a discovery was made and what corpus version it was based on.
The X-Vault WORM log is stored server-side and is never rewritten — only appended to. Anyone who purchases a discovery license receives the event hash and chain hash, which can be independently verified at biohacksai.com/verify.
Visualising how a compound works
Every discovery includes a mechanism discovery graph — a force-directed visualisation showing the relationship between the compound, its molecular targets, and the biological pathways those targets regulate.
Fixed at centre. The compound being analysed.
The gene/protein targets the compound interacts with. Colour-coded by drug-discovery relevance: gold = Tier 3 (patent-relevant kinases and TFs), indigo = Tier 2 (research targets), teal = standard targets. A pulsing dashed ring marks Tier 3 targets with ≤ 5 studies — the knowledge gap indicator.
The biological systems those targets belong to (Reactome). Shown as dashed rectangles connected by dotted lines from their associated targets.
Discovery licenses
Discoveries can be licensed in two ways. Both include the full discovery report PDF, X-Vault seal reference, and a signed license agreement issued within 24 hours.
- ✓ Full discovery report PDF (20–30 pages)
- ✓ X-Vault seal + public verification link
- ✓ Research and publication rights
- ✓ 10% royalty to buyer if patent arises
- ✓ Multiple buyers permitted
- ✓ Everything in Shared
- ✓ Commercial + patent filing rights
- ✓ Single buyer — exclusivity guaranteed
- ✓ 90% IP transferred to buyer
- ✓ Exclusivity recorded in X-Vault
Purchases are handled by email to hello@biohacksai.com. Include the Discovery ID in your subject line.
AI proposes. Humans decide.
BiohacksAI is built on the EVE (Evidence & Verification Engine) architecture developed by Organiq Sweden AB. The core principle is witness mode: the AI generates hypotheses and surfaces evidence, but all decisions are made by humans and recorded with human-controlled cryptographic keys.
- — The discovery engine never licenses anything autonomously
- — Every discovery seal requires a verified admin key
- — License agreements are signed by humans, not auto-generated
- — The system logs what it proposed and when — the human logs what they decided
- — No discovery can be unsealed or retroactively altered
All discoveries are labelled as computational hypothesis candidates — not confirmed mechanisms. Independent experimental validation is always required. Patent eligibility must be assessed by qualified patent counsel. IP assessments on this platform are computational only and do not constitute legal advice.
Verify any discovery
Anyone can verify a discovery — no account required. Paste a Discovery ID (format: DISC-compound-YYYYMMDD-xxxxxxxx) or any part of the event hash into the verification page. The system walks the X-Vault chain and confirms whether the discovery exists and whether the chain integrity is intact.
Sources & licenses
BiohacksAI is built on publicly available scientific databases. We are grateful to the teams behind these resources.
Data is used for non-commercial research and hypothesis generation. Bioactivity records from ChEMBL and BindingDB are aggregated and scored; individual assay records are not redistributed. If you believe any usage conflicts with a source license, contact hello@biohacksai.com.