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BiohacksAI/Substances/Best for Longevity & Anti-Aging
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Best Compounds for Longevity & Anti-Aging

Longevity research has accelerated dramatically, with several compounds now showing evidence for extending healthspan through multiple mechanisms including NAD⁺ metabolism, mTOR inhibition, sirtuin activation, and senescent cell clearance. The compounds below are ranked by PubMed study count and evidence strength from the BiohacksAI corpus. Each has documented interactions with key longevity pathways including AMPK, SIRT1, and autophagy regulation.

SIRT pathway →mTOR pathway →AMPK pathway →AUTOPHAGY pathway →
Top 30 Compounds — Ranked by Evidence
Based on PubMed study count and pathway overlap · BiohacksAI corpus
1
Berberinefeatured
300
studies
2
Fisetinfeatured
78
studies
3
Metforminfeatured
1,000
studies
4
Nmnfeatured
300
studies
5
Quercetinfeatured
300
studies
6
Rapamycinfeatured
300
studies
7
Resveratrolfeatured
298
studies
8
Spermidinefeatured
241
studies
9
Budesonide
1,000
studies
10
Sertraline
1,000
studies
11
Metoprolol
1,000
studies
12
Pembrolizumab
1,000
studies
13
Ibuprofen
1,000
studies
14
Amlodipine
1,000
studies
15
Insulin
1,000
studies
16
Rituximab
1,000
studies
17
Prednisolone
1,000
studies
18
Trastuzumab
1,000
studies
19
Azithromycin
1,000
studies
20
Tramadol
1,000
studies
21
Warfarin
1,000
studies
22
Atorvastatin
1,000
studies
23
Aspirin
1,000
studies
24
Semaglutide
999
studies
25
Diazepam
999
studies
26
Rivaroxaban
999
studies
27
Liraglutide
999
studies
28
Empagliflozin
996
studies
29
Levothyroxine
994
studies
30
Prunus Avium
500
studies
Key Molecular Targets
SIRT1MTORPRKAA1PRKAA2TP53FOXO3

Click a target to explore all compounds with documented interactions.

Related Goals
🧊 Anti-Inflammatory⚡ Mitochondrial Function🧘 Stress & Cortisol

Rankings are based on PubMed study count, pathway overlap, and BiohacksAI discovery score — a deterministic algorithm weighing evidence quality, study type, and research velocity. All data is Merkle-verified for reproducibility.

Explore more: Browse all compounds · Biological pathways · Molecular targets

Data from PubMed/NCBI, BindingDB, and Reactome. Not medical advice. © Organiq Sweden AB.