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BiohacksAI/Pathways/Insulin / IGF-1 Signaling
PATHWAYGrowth Signaling

Insulin / IGF-1 Signaling

PI3K-AKT-FOXO axis — reduced signaling associated with longevity in model organisms

3,083 compounds · BiohacksAI corpus

3,083
compounds
Compounds
3,083
Category
Growth Signaling
Pathway ID
INSULIN_SIGNALING
MeSH Terms
InsulinInsulin ResistanceInsulin-Like Growth Factor IReceptor, InsulinProto-Oncogene Proteins c-aktPhosphatidylinositol 3-KinasesFOXO Transcription FactorsForkhead Transcription FactorsBlood GlucoseGlycated Hemoglobin
Top Compounds — Insulin / IGF-1 Signaling (50 of 3,083)
1
Insulin
1,000
studies
70.5
evidence
2
Metformin
1,000
studies
73.5
evidence
3
Losartan
1,000
studies
75.0
evidence
4
Simvastatin
1,000
studies
73.6
evidence
5
Atorvastatin
1,000
studies
76.1
evidence
6
Metoprolol
1,000
studies
75.7
evidence
7
Amlodipine
1,000
studies
75.7
evidence
8
Salbutamol
297
studies
76.1
evidence
9
Prednisolone
1,000
studies
79.5
evidence
10
Fluoxetine
1,000
studies
75.8
evidence
11
Sertraline
1,000
studies
76.2
evidence
12
Trastuzumab
1,000
studies
75.4
evidence
13
Aspirin
1,000
studies
69.5
evidence
14
Paracetamol
1,000
studies
77.1
evidence
15
Venlafaxine
1,000
studies
74.1
evidence
16
Ciprofloxacin
1,000
studies
73.7
evidence
17
Ibuprofen
1,000
studies
78.8
evidence
18
Azithromycin
1,000
studies
78.3
evidence
19
Budesonide
1,000
studies
80.1
evidence
20
Naproxen
1,000
studies
74.8
evidence
21
Tramadol
1,000
studies
77.9
evidence
22
Warfarin
1,000
studies
65.0
evidence
23
Amoxicillin
1,000
studies
79.4
evidence
24
Pembrolizumab
1,000
studies
73.3
evidence
25
Rituximab
1,000
studies
74.1
evidence
26
Liraglutide
999
studies
76.7
evidence
27
Semaglutide
999
studies
69.9
evidence
28
Doxycycline
999
studies
76.8
evidence
29
Diazepam
999
studies
73.0
evidence
30
Empagliflozin
996
studies
73.3
evidence
31
Pregabalin
996
studies
77.1
evidence
32
Escitalopram
995
studies
74.8
evidence
33
Levothyroxine
994
studies
64.3
evidence
34
Quetiapine
994
studies
73.6
evidence
35
Duloxetine
993
studies
73.0
evidence
36
Sitagliptin
990
studies
72.1
evidence
37
Montelukast
985
studies
69.1
evidence
38
Lisinopril
904
studies
68.6
evidence
39
Momordica_charantia
500
studies
38.6
evidence
40
Galanin
500
studies
43.1
evidence
41
Portulaca_oleracea
500
studies
38.3
evidence
42
Neuropeptide_y
500
studies
44.2
evidence
43
Hibiscus_sabdariffa
500
studies
41.3
evidence
44
Ocimum_sanctum
500
studies
38.1
evidence
45
Moringa_oleifera
500
studies
37.8
evidence
46
Nelumbo__nucifera
500
studies
39.5
evidence
47
Nelumbo_nucifera
500
studies
39.5
evidence
48
Psoralea_corylifolia
500
studies
37.1
evidence
49
Juglans_regia
500
studies
38.7
evidence
50
Curcuma_longa
500
studies
39.8
evidence

Data from PubMed, BindingDB, and Reactome. Not medical advice.