What compounds affect the Transmission across Chemical Synapses pathway?

388 compounds in the BiohacksAI corpus have documented interactions with genes in the Transmission across Chemical Synapses pathway (Reactome ID: R-HSA-112315). These compounds target 110 genes within this pathway.

What genes are in the Transmission across Chemical Synapses pathway?

The Transmission across Chemical Synapses pathway involves 110 genes. Key genes include: ABAT, ACHE, ADCY9, ALDH2, ALDH5A1, BCHE, CACNA1B, CACNA2D1, CACNA2D2, CAMK1.

Transmission across Chemical Synapses

REACTOME PATHWAY

Reactome: R-HSA-112315110 genes388 compounds

The Transmission across Chemical Synapses pathway (Reactome ID: R-HSA-112315) involves 110 genes and is affected by 388 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABAT ACHE ADCY9 ALDH2 ALDH5A1 BCHE CACNA1B CACNA2D1 CACNA2D2 CAMK1 CAMK2B CAMK2D CAMKK1 CAMKK2 CASK CHRNA1 CHRNA4 CHRND CHRNG CREB1 ERBB4 GABBR1 GABBR2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1+80 more

Compounds Affecting Transmission across Chemical Synapses

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	gamma-Aminobutyric Acid	—	300
3	Ondansetron	—	299
4	Nocodazole Nocodazole is	—	215
5	Picrotoxin	—	300
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Demecolcine	—	246
8	Podophyllotoxin	—	14
9	vinblastine sulfate	—	81
10	Vorinostat	—	299
11	Vincristine	—	299
12	Noscapine	—	300
13	chrysin	—	300
14	Maytansine	—	300
15	Pregnanolone	—	298
16	Bicuculline	—	300
17	Etomidate Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or	—	299
18	Glutamic Acid	—	297
19	Glutamic Acid	—	300
20	Androsterone	—	300
21	Ciprofloxacin	—	1,000
22	Etiocholanolone	—	300
23	Triiodothyronine	—	300
24	Aripiprazole	—	298
25	sp600125	—	117
26	Berberine	—	300
27	Niclosamide	—	299
28	Adenosine Monophosphate Adenine nucleotide containing	—	300
29	pentamidine	—	299
30	Sorafenib	—	300
31	Ursolic Acid	—	300
32	Rotenone	—	300
33	Ethidium	—	300
34	hydroxyfasudil [Supplementary Concept]	—	11
35	Eszopiclone	—	296
36	Proguanil	—	299
37	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
38	Antimycin	—	300
39	Oleanolic Acid	—	300
40	Metformin	—	1,000
41	Astemizole Antihistamine drug now withdrawn from	—	280
42	Chlorhexidine	—	299
43	Crizotinib	—	298
44	Nortriptyline	—	295
45	Quercetin	—	300
46	Metoclopramide	—	297
47	Quipazine	—	300
48	Mianserin	—	299
49	Levorphanol	—	297
50	Aspartic Acid	—	300

About the Transmission across Chemical Synapses Pathway

The Transmission across Chemical Synapses pathway is catalogued in Reactome (ID: R-HSA-112315) and involves 110 genes. In the BiohacksAI corpus, 388 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABAT, ACHE, ADCY9, ALDH2, ALDH5A1.