What compounds affect the Adaptive Immune System pathway?

483 compounds in the BiohacksAI corpus have documented interactions with genes in the Adaptive Immune System pathway (Reactome ID: R-HSA-1280218). These compounds target 165 genes within this pathway.

What genes are in the Adaptive Immune System pathway?

The Adaptive Immune System pathway involves 165 genes. Key genes include: ADRM1, AGO2, AKT3, ASH2L, BLK, BRD4, BTK, CD74, CDC42, CDK4.

Adaptive Immune System

REACTOME PATHWAY

Reactome: R-HSA-1280218165 genes483 compounds

The Adaptive Immune System pathway (Reactome ID: R-HSA-1280218) involves 165 genes and is affected by 483 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AGO2 AKT3 ASH2L BLK BRD4 BTK CD74 CDC42 CDK4 CHUK COPS5 CREBBP CSK CSNK2A1 CSNK2A2 CSNK2B CTSA CTSL CUL1 CYBB DPY30 EED EP300 EPAS1 EZH2 FKBP1A FOS FYN GRB2+135 more

Compounds Affecting Adaptive Immune System

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Colchicine	—	300
3	Nocodazole Nocodazole is	—	215
4	Quercetin	—	300
5	Podophyllotoxin	—	14
6	vinblastine sulfate	—	81
7	Vincristine	—	299
8	Reserpine	—	297
9	Crizotinib	—	298
10	Vorinostat	—	299
11	ly294002	—	11
12	Demecolcine	—	246
13	Noscapine	—	300
14	Kaempferols	—	300
15	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
16	Sorafenib	—	300
17	Maytansine	—	300
18	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
19	Niclosamide	—	299
20	Rotenone	—	300
21	sp600125	—	117
22	Oleanolic Acid	—	300
23	Antimycin	—	300
24	Dasatinib	—	299
25	Ursolic Acid	—	300
26	pictilisib	—	25
27	Resveratrol	—	298
28	chrysin	—	300
29	kenpaullone	—	8
30	egcg	—	300
31	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
32	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
33	Sirolimus	—	300
34	Hexachlorophene	—	300
35	Axitinib	—	298
36	torin 1	—	10
37	tyrphostin ag 1478	—	4
38	Berberine	—	300
39	alsterpaullone	—	12
40	Wortmannin	—	300
41	Adenosine Monophosphate Adenine nucleotide containing	—	300
42	Genistein	—	300
43	Disulfiram	—	297
44	cycloheximide	—	300
45	alpelisib	—	227
46	Proguanil	—	299
47	Metformin	—	1,000
48	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
49	Daunorubicin	—	298
50	Clotrimazole	—	296

About the Adaptive Immune System Pathway

The Adaptive Immune System pathway is catalogued in Reactome (ID: R-HSA-1280218) and involves 165 genes. In the BiohacksAI corpus, 483 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AGO2, AKT3, ASH2L, BLK.