What compounds affect the Recycling of bile acids and salts pathway?

190 compounds in the BiohacksAI corpus have documented interactions with genes in the Recycling of bile acids and salts pathway (Reactome ID: R-HSA-159418). These compounds target 11 genes within this pathway.

What genes are in the Recycling of bile acids and salts pathway?

The Recycling of bile acids and salts pathway involves 11 genes. Key genes include: ABCB11, ABCC3, ALB, NCOA1, NR1H4, RXRA, SLC10A1, SLC10A2, SLCO1A2, SLCO1B1.

Recycling of bile acids and salts

REACTOME PATHWAY

Reactome: R-HSA-15941811 genes190 compounds

The Recycling of bile acids and salts pathway (Reactome ID: R-HSA-159418) involves 11 genes and is affected by 190 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCB11 ABCC3 ALB NCOA1 NR1H4 RXRA SLC10A1 SLC10A2 SLCO1A2 SLCO1B1 SLCO1B3

Compounds Affecting Recycling of bile acids and salts

#	Compound	Targets Hit	Studies
1	Taurocholic Acid	—	300
2	Olmesartan Medoxomil	—	300
3	Genistein	—	300
4	Mometasone Furoate	—	292
5	Thyroxine	—	994
6	Taurochenodeoxycholic Acid	—	300
7	Thyroxine	—	300
8	Rifamycins	—	300
9	Rifamycins	—	300
10	Chenodeoxycholic Acid	—	299
11	Ursodeoxycholic Acid	—	298
12	Rotenone	—	300
13	Atorvastatin	—	1,000
14	Progesterone	—	299
15	Simvastatin	—	1,000
16	Methotrexate	—	289
17	Glycochenodeoxycholic Acid	—	300
18	Arachidonic Acid	—	245
19	Gemfibrozil	—	297
20	Ritonavir	—	298
21	Losartan	—	1,000
22	beta Carotene	—	299
23	Triiodothyronine	—	300
24	Cholic Acid	—	299
25	Ethidium	—	300
26	Ethinyl Estradiol	—	300
27	Methylene Blue	—	200
28	Clotrimazole	—	296
29	Dactinomycin	—	297
30	Azacitidine	—	298
31	Azacitidine	—	300
32	Dihydrotestosterone	—	300
33	Retinaldehyde	—	300
34	Troglitazone	—	299
35	Vincristine	—	299
36	Glyburide	—	298
37	Irbesartan	—	298
38	Sirolimus	—	300
39	Rimonabant	—	300
40	Bilirubin	—	296
41	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
42	candesartan cilexetil [Supplementary Concept]	—	300
43	Antimycin	—	300
44	Digoxin	—	299
45	Silymarin	—	10
46	obeticholic acid [Supplementary Concept]	—	271
47	Lithocholic Acid	—	300
48	Resveratrol	—	298
49	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
50	Apigenin 5,7,4'-trihydroxy-flavone,	—	300

About the Recycling of bile acids and salts Pathway

The Recycling of bile acids and salts pathway is catalogued in Reactome (ID: R-HSA-159418) and involves 11 genes. In the BiohacksAI corpus, 190 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCB11, ABCC3, ALB, NCOA1, NR1H4.