DDX58/IFIH1-mediated induction of interferon-alpha/beta

Q: What compounds affect the DDX58/IFIH1-mediated induction of interferon-alpha/beta pathway?

127 compounds in the BiohacksAI corpus have documented interactions with genes in the DDX58/IFIH1-mediated induction of interferon-alpha/beta pathway (Reactome ID: R-HSA-168928). These compounds target 18 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-16892818 genes127 compounds

The DDX58/IFIH1-mediated induction of interferon-alpha/beta pathway (Reactome ID: R-HSA-168928) involves 18 genes and is affected by 127 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APP CHUK CREBBP EP300 HMGB1 HSP90AA1 HSP90AB1 IFNB1 IKBKB IKBKE MAP3K1 NFKB1 NFKB2 NFKBIA PIN1 RELA S100B TBK1

Compounds Affecting DDX58/IFIH1-mediated induction of interferon-alpha/beta

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Crizotinib	—	298
3	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
4	withaferin	—	300
5	Disulfiram	—	297
6	Bortezomib	—	300
7	Resveratrol	—	298
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	Kaempferols	—	300
10	chicoric acid	—	117
11	celastrol	—	300
12	Idarubicin	—	299
13	triolimus [Supplementary Concept]	—	33
14	Podophyllotoxin	—	14
15	egcg	—	300
16	Rutin	—	300
17	Withania	—	500
18	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
19	tamarixetin	—	26
20	Trifluridine	—	295
21	caffeic acid	—	300
22	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
23	Ouabain	—	300
24	cycloheximide	—	300
25	Calcimycin	—	216
26	Digitoxin	—	300
27	Digoxin	—	299
28	Methylene Blue	—	200
29	Sorafenib	—	300
30	sp600125	—	117
31	tyrphostin ag 1478	—	4
32	Hexachlorophene	—	300
33	streptonigrin	—	299
34	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
35	monorden	—	8
36	gedunin	—	54
37	Novobiocin	—	300
38	Masoprocol	—	300
39	Tetracycline	—	300
40	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
41	ag490	—	14
42	piceatannol	—	300
43	Nitroprusside	—	299
44	plumbagin [Supplementary Concept]	—	300
45	Aurintricarboxylic Acid	—	184
46	amlexanox	—	96
47	Camptothecin	—	300
48	Emetine	—	298
49	Proscillaridin	—	219
50	Dactinomycin	—	297

About the DDX58/IFIH1-mediated induction of interferon-alpha/beta Pathway

The DDX58/IFIH1-mediated induction of interferon-alpha/beta pathway is catalogued in Reactome (ID: R-HSA-168928) and involves 18 genes. In the BiohacksAI corpus, 127 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, CHUK, CREBBP, EP300, HMGB1.