What compounds affect the Pre-NOTCH Expression and Processing pathway?

222 compounds in the BiohacksAI corpus have documented interactions with genes in the Pre-NOTCH Expression and Processing pathway (Reactome ID: R-HSA-1912422). These compounds target 14 genes within this pathway.

What genes are in the Pre-NOTCH Expression and Processing pathway?

The Pre-NOTCH Expression and Processing pathway involves 14 genes. Key genes include: AGO2, ATP2A1, ATP2A2, ATP2A3, CREBBP, ELANE, EP300, FURIN, JUN, KAT2A.

Pre-NOTCH Expression and Processing

REACTOME PATHWAY

Reactome: R-HSA-191242214 genes222 compounds

The Pre-NOTCH Expression and Processing pathway (Reactome ID: R-HSA-1912422) involves 14 genes and is affected by 222 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AGO2 ATP2A1 ATP2A2 ATP2A3 CREBBP ELANE EP300 FURIN JUN KAT2A KAT2B RUNX1 SIRT6 TP53

Compounds Affecting Pre-NOTCH Expression and Processing

#	Compound	Targets Hit	Studies
1	Disulfiram	—	297
2	plumbagin [Supplementary Concept]	—	300
3	Nocodazole Nocodazole is	—	215
4	Colchicine	—	300
5	egcg	—	300
6	Ethidium	—	300
7	Hexachlorophene	—	300
8	Methylene Blue	—	200
9	Bortezomib	—	300
10	Rotenone	—	300
11	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
12	Daunorubicin	—	298
13	Vitamin K 3	—	300
14	Quercetin	—	300
15	ninhydrin	—	300
16	Estramustine	—	300
17	Clotrimazole	—	296
18	Methylnitronitrosoguanidine	—	52
19	Thioridazine	—	35
20	vinblastine sulfate	—	81
21	Clofibrate	—	299
22	Fenofibrate	—	297
23	Harmaline	—	300
24	Iodoacetamide	—	300
25	Nisoldipine	—	297
26	Oxyphenbutazone	—	300
27	rafoxanide	—	172
28	triflupromazine hydrochloride	—	12
29	Vincristine	—	299
30	Sertraline	—	1,000
31	alpha-Linolenic Acid	—	300
32	Amoxapine	—	259
33	Chlormadinone Acetate	—	300
34	Cinnarizine	—	299
35	diallyl trisulfide	—	246
36	ethopropazine hydrochloride	—	2
37	Ethynodiol Diacetate	—	300
38	Maprotiline	—	299
39	Robenidine	—	162
40	Salmeterol Xinafoate	—	227
41	Thapsigargin	—	300
42	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
43	DEAD-box RNA Helicases	—	169
44	Thioctic Acid	—	298
45	Thioctic Acid	—	300
46	Lithocholic Acid	—	300
47	Aurintricarboxylic Acid	—	184
48	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
49	paxilline	—	42
50	Ethinyl Estradiol	—	300

About the Pre-NOTCH Expression and Processing Pathway

The Pre-NOTCH Expression and Processing pathway is catalogued in Reactome (ID: R-HSA-1912422) and involves 14 genes. In the BiohacksAI corpus, 222 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AGO2, ATP2A1, ATP2A2, ATP2A3, CREBBP.