What compounds affect the Bile acid and bile salt metabolism pathway?

199 compounds in the BiohacksAI corpus have documented interactions with genes in the Bile acid and bile salt metabolism pathway (Reactome ID: R-HSA-194068). These compounds target 18 genes within this pathway.

What genes are in the Bile acid and bile salt metabolism pathway?

The Bile acid and bile salt metabolism pathway involves 18 genes. Key genes include: ABCB11, ABCC3, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALB, CYP46A1, CYP8B1, NCOA1.

Bile acid and bile salt metabolism

REACTOME PATHWAY

Reactome: R-HSA-19406818 genes199 compounds

The Bile acid and bile salt metabolism pathway (Reactome ID: R-HSA-194068) involves 18 genes and is affected by 199 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCB11 ABCC3 AKR1C1 AKR1C2 AKR1C3 AKR1C4 ALB CYP46A1 CYP8B1 NCOA1 NR1H4 OSBP RXRA SLC10A1 SLC10A2 SLCO1A2 SLCO1B1 SLCO1B3

Compounds Affecting Bile acid and bile salt metabolism

#	Compound	Targets Hit	Studies
1	Taurocholic Acid	—	300
2	Olmesartan Medoxomil	—	300
3	Genistein	—	300
4	Mometasone Furoate	—	292
5	Thyroxine	—	994
6	Progesterone	—	299
7	Taurochenodeoxycholic Acid	—	300
8	Thyroxine	—	300
9	Rifamycins	—	300
10	Rifamycins	—	300
11	Chenodeoxycholic Acid	—	299
12	Ursodeoxycholic Acid	—	298
13	Rotenone	—	300
14	Clotrimazole	—	296
15	Atorvastatin	—	1,000
16	Simvastatin	—	1,000
17	Methotrexate	—	289
18	Glycochenodeoxycholic Acid	—	300
19	Arachidonic Acid	—	245
20	Gemfibrozil	—	297
21	Ritonavir	—	298
22	Losartan	—	1,000
23	beta Carotene	—	299
24	Triiodothyronine	—	300
25	Medroxyprogesterone Acetate	—	299
26	Cholic Acid	—	299
27	Ethidium	—	300
28	Ethinyl Estradiol	—	300
29	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
30	Methylene Blue	—	200
31	Dactinomycin	—	297
32	chrysin	—	300
33	Azacitidine	—	298
34	Azacitidine	—	300
35	Dihydrotestosterone	—	300
36	Retinaldehyde	—	300
37	Troglitazone	—	299
38	Vincristine	—	299
39	Testosterone	—	299
40	Glyburide	—	298
41	Irbesartan	—	298
42	Sirolimus	—	300
43	Econazole	—	299
44	Miconazole	—	298
45	Rimonabant	—	300
46	Bilirubin	—	296
47	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
48	candesartan cilexetil [Supplementary Concept]	—	300
49	Antimycin	—	300
50	Digoxin	—	299

About the Bile acid and bile salt metabolism Pathway

The Bile acid and bile salt metabolism pathway is catalogued in Reactome (ID: R-HSA-194068) and involves 18 genes. In the BiohacksAI corpus, 199 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCB11, ABCC3, AKR1C1, AKR1C2, AKR1C3.