What compounds affect the Signaling by NOTCH1 pathway?

131 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by NOTCH1 pathway (Reactome ID: R-HSA-1980143). These compounds target 33 genes within this pathway.

What genes are in the Signaling by NOTCH1 pathway?

The Signaling by NOTCH1 pathway involves 33 genes. Key genes include: ADAM10, ADAM17, APH1A, APH1B, ARRB1, CCNC, CDK8, CREBBP, CUL1, DLK1.

Signaling by NOTCH1

REACTOME PATHWAY

Reactome: R-HSA-198014333 genes131 compounds

The Signaling by NOTCH1 pathway (Reactome ID: R-HSA-1980143) involves 33 genes and is affected by 131 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM10 ADAM17 APH1A APH1B ARRB1 CCNC CDK8 CREBBP CUL1 DLK1 EP300 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HIF1A KAT2A KAT2B MYC NCOR1 NCOR2 NCSTN PSEN1+3 more

Compounds Affecting Signaling by NOTCH1

#	Compound	Targets Hit	Studies
1	Vorinostat	—	299
2	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
3	Camptothecin	—	300
4	scriptaid	—	53
5	pictilisib	—	25
6	Valproic Acid	—	296
7	Butyric Acid	—	300
8	Ursolic Acid	—	300
9	Celecoxib	—	295
10	Daunorubicin	—	298
11	Chlorogenic Acid	—	300
12	gamma-Aminobutyric Acid	—	300
13	Dihydroergocristine	—	187
14	Bortezomib	—	300
15	Kaempferols	—	300
16	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
17	chrysin	—	300
18	egcg	—	300
19	Quercetin	—	300
20	Axitinib	—	298
21	Resveratrol	—	298
22	Hesperidin	—	300
23	Niclosamide	—	299
24	Oxytetracycline	—	300
25	sp600125	—	117
26	Genistein	—	300
27	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
28	Pueraria	—	300
29	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
30	Febuxostat	—	297
31	Nocodazole Nocodazole is	—	215
32	Iodoacetamide	—	300
33	Bufexamac	—	137
34	candesartan cilexetil [Supplementary Concept]	—	300
35	Hexachlorophene	—	300
36	Bisphenol A-Glycidyl Methacrylate	—	197
37	Sorafenib	—	300
38	plumbagin [Supplementary Concept]	—	300
39	ninhydrin	—	300
40	Emetine	—	298
41	cycloheximide	—	300
42	Topotecan	—	300
43	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
44	Gliotoxin	—	300
45	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
46	Harmaline	—	300
47	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
48	Loratadine	—	296
49	oxatomide [Supplementary Concept] structure;	—	128
50	triolimus [Supplementary Concept]	—	33

About the Signaling by NOTCH1 Pathway

The Signaling by NOTCH1 pathway is catalogued in Reactome (ID: R-HSA-1980143) and involves 33 genes. In the BiohacksAI corpus, 131 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM10, ADAM17, APH1A, APH1B, ARRB1.