NOTCH1 Intracellular Domain Regulates Transcription

Q: What compounds affect the NOTCH1 Intracellular Domain Regulates Transcription pathway?

123 compounds in the BiohacksAI corpus have documented interactions with genes in the NOTCH1 Intracellular Domain Regulates Transcription pathway (Reactome ID: R-HSA-2122947). These compounds target 23 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-212294723 genes123 compounds

The NOTCH1 Intracellular Domain Regulates Transcription pathway (Reactome ID: R-HSA-2122947) involves 23 genes and is affected by 123 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCNC CDK8 CREBBP CUL1 EP300 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HIF1A KAT2A KAT2B MYC NCOR1 NCOR2 RBX1

Compounds Affecting NOTCH1 Intracellular Domain Regulates Transcription

#	Compound	Targets Hit	Studies
1	Vorinostat	—	299
2	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
3	Camptothecin	—	300
4	scriptaid	—	53
5	pictilisib	—	25
6	Valproic Acid	—	296
7	Butyric Acid	—	300
8	Ursolic Acid	—	300
9	Celecoxib	—	295
10	Daunorubicin	—	298
11	Chlorogenic Acid	—	300
12	gamma-Aminobutyric Acid	—	300
13	Bortezomib	—	300
14	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
15	chrysin	—	300
16	egcg	—	300
17	Kaempferols	—	300
18	Quercetin	—	300
19	Resveratrol	—	298
20	Hesperidin	—	300
21	Niclosamide	—	299
22	Oxytetracycline	—	300
23	sp600125	—	117
24	Genistein	—	300
25	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
26	Pueraria	—	300
27	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
28	Axitinib	—	298
29	Febuxostat	—	297
30	Nocodazole Nocodazole is	—	215
31	Iodoacetamide	—	300
32	Bufexamac	—	137
33	candesartan cilexetil [Supplementary Concept]	—	300
34	Sorafenib	—	300
35	plumbagin [Supplementary Concept]	—	300
36	ninhydrin	—	300
37	Emetine	—	298
38	cycloheximide	—	300
39	Topotecan	—	300
40	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
41	Gliotoxin	—	300
42	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
43	Harmaline	—	300
44	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
45	Loratadine	—	296
46	oxatomide [Supplementary Concept] structure;	—	128
47	triolimus [Supplementary Concept]	—	33
48	Hydrocortisone	—	299
49	2-Chloroadenosine 2-Chloroadenosine.	—	300
50	ag490	—	14

About the NOTCH1 Intracellular Domain Regulates Transcription Pathway

The NOTCH1 Intracellular Domain Regulates Transcription pathway is catalogued in Reactome (ID: R-HSA-2122947) and involves 23 genes. In the BiohacksAI corpus, 123 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNC, CDK8, CREBBP, CUL1, EP300.