Transcriptional activation of mitochondrial biogenesis

Q: What compounds affect the Transcriptional activation of mitochondrial biogenesis pathway?

304 compounds in the BiohacksAI corpus have documented interactions with genes in the Transcriptional activation of mitochondrial biogenesis pathway (Reactome ID: R-HSA-2151201). These compounds target 13 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-215120113 genes304 compounds

The Transcriptional activation of mitochondrial biogenesis pathway (Reactome ID: R-HSA-2151201) involves 13 genes and is affected by 304 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CARM1 CREB1 CREBBP ESRRA HDAC3 NCOA1 NCOR1 NR1D1 POLRMT PPARA RXRA SIRT3 SIRT5

Compounds Affecting Transcriptional activation of mitochondrial biogenesis

#	Compound	Targets Hit	Studies
1	Genistein	—	300
2	Azacitidine	—	298
3	Azacitidine	—	300
4	cycloheximide	—	300
5	Ethidium	—	300
6	Bortezomib	—	300
7	Quercetin	—	300
8	Nocodazole Nocodazole is	—	215
9	Testosterone	—	299
10	Dactinomycin	—	297
11	Daunorubicin	—	298
12	Gemfibrozil	—	297
13	Aldosterone	—	300
14	Fulvestrant	—	295
15	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
16	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
17	Rotenone	—	300
18	Methotrexate	—	289
19	Disulfiram	—	297
20	Flutamide	—	298
21	Niclosamide	—	299
22	Hexachlorophene	—	300
23	Methylene Blue	—	200
24	Dihydrotestosterone	—	300
25	Progesterone	—	299
26	chrysin	—	300
27	Danazol	—	298
28	Fenofibrate	—	297
29	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
30	Nisoldipine	—	297
31	trequinsin hydrochloride	—	1
32	Celecoxib	—	295
33	Cilostazol	—	297
34	Cladribine	—	297
35	Clofarabine	—	298
36	Corticosterone	—	300
37	Dasatinib	—	299
38	Digoxin	—	299
39	Domperidone	—	299
40	Ethinyl Estradiol	—	300
41	Ezetimibe	—	296
42	Adenosine Monophosphate Adenine nucleotide containing	—	300
43	Dinoprostone	—	296
44	Emetine	—	298
45	Epinephrine	—	299
46	Imatinib Mesylate	—	300
47	Nitrofurazone	—	300
48	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
49	Retinaldehyde	—	300
50	Troglitazone	—	299

About the Transcriptional activation of mitochondrial biogenesis Pathway

The Transcriptional activation of mitochondrial biogenesis pathway is catalogued in Reactome (ID: R-HSA-2151201) and involves 13 genes. In the BiohacksAI corpus, 304 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CARM1, CREB1, CREBBP, ESRRA, HDAC3.