What compounds affect the Cellular Senescence pathway?

282 compounds in the BiohacksAI corpus have documented interactions with genes in the Cellular Senescence pathway (Reactome ID: R-HSA-2559583). These compounds target 41 genes within this pathway.

What genes are in the Cellular Senescence pathway?

The Cellular Senescence pathway involves 41 genes. Key genes include: ATM, CCNA1, CCNE2, CDK2, CDK4, CDK6, CXCL8, EED, EHMT1, EHMT2.

Cellular Senescence

REACTOME PATHWAY

Reactome: R-HSA-255958341 genes282 compounds

The Cellular Senescence pathway (Reactome ID: R-HSA-2559583) involves 41 genes and is affected by 282 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATM CCNA1 CCNE2 CDK2 CDK4 CDK6 CXCL8 EED EHMT1 EHMT2 EZH2 FOS IFNB1 IL6 JUN KDM6B MAP2K3 MAP2K4 MAP3K5 MAP4K4 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK5+11 more

Compounds Affecting Cellular Senescence

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	Sorafenib	—	300
3	withaferin	—	300
4	fisetin	—	78
5	Quercetin	—	300
6	Anisomycin	—	247
7	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
8	alsterpaullone	—	12
9	Methylene Blue	—	200
10	Disulfiram	—	297
11	Axitinib	—	298
12	kenpaullone	—	8
13	Afatinib	—	297
14	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
15	Trifluridine	—	295
16	vinblastine sulfate	—	81
17	Sertraline	—	1,000
18	Colchicine	—	300
19	Dasatinib	—	299
20	Podophyllotoxin	—	14
21	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
22	Hexachlorophene	—	300
23	Azacitidine	—	298
24	Azacitidine	—	300
25	Bortezomib	—	300
26	Niclosamide	—	299
27	ninhydrin	—	300
28	plumbagin [Supplementary Concept]	—	300
29	cycloheximide	—	300
30	Thioridazine	—	35
31	Digoxin	—	299
32	Nisoldipine	—	297
33	Nocodazole Nocodazole is	—	215
34	Oxyphenbutazone	—	300
35	Astemizole Antihistamine drug now withdrawn from	—	280
36	egcg	—	300
37	Lovastatin	—	300
38	Calcimycin	—	216
39	streptonigrin	—	299
40	cardamonin	—	180
41	Crizotinib	—	298
42	tyrphostin ag 1478	—	4
43	pictilisib	—	25
44	Cladribine	—	297
45	Cytarabine	—	297
46	Melphalan	—	300
47	Methotrexate	—	289
48	Genistein	—	300
49	Resveratrol	—	298
50	Ciclopirox	—	88

About the Cellular Senescence Pathway

The Cellular Senescence pathway is catalogued in Reactome (ID: R-HSA-2559583) and involves 41 genes. In the BiohacksAI corpus, 282 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATM, CCNA1, CCNE2, CDK2, CDK4.